The effect of halothane on myocardial infarction caused by ligation of the left descending coronary artery was studied in rats. The extent of infarction was quantified 48 hours after ligation of the artery by planimetric measurement of left ventricular slices stained with nitrobluetetrazolium. Animals exposed to halothane one per cent for three hours after the coronary ligation were compared wi...

BACKGROUND We have previously reported that halothane anaesthesia increases the extracellular concentration of dopamine (DA) metabolites in the rat striatum with no change in DA. Although the metabolism of catecholamines is a source of oxidative stress, there is little information about DA metabolism and anaesthesia. We assessed the mechanism(s) of enhanced DA metabolism induced by halothane. ...

MITCHELSON, K. R., AND F. J. R. HIRD. Effect of pH and halothane on muscle and liver mitochondria. Am. J. Physiol. 225(6) : 1393-l 398. 1973.-The separate and combined effects of hydrogen ions and of the anesthetic halothane on skeletal muscle mitochondria have been studied using pyruvate plus malate as the substrate. Below pH ‘6.5 and pH 6.0 there was a rapid fall in State 3 respiration and th...

To determine the effect of inhalation anaesthetics on the plasma concentration of laudanosine necessary to produce CNS excitation, we administered laudanosine 0.5 mg kg-1 min-1 i.v. to 40 rabbits under eight study conditions: 1.0 or 0.7% halothane, 1.6% isoflurane, 2.0% enflurane, during normocapnia and hypocapnia; 70% nitrous oxide, alone and with 1.0% halothane, and room air (control). At the...

The effects of halothane (1.0-1.5%) on myocardial contractility, systemic vascular resistance (representing the majority of impedance to oscillatory flow), and left ventricular performance, and the interactions of these functions have been studied in openchested dogs, artificially ventilated and maintained in a state of basal narcosis with chloralose and urethane. Halothane reversibly depressed...

Halothane was first synthesized by Suckling in 1952 and introduced into clinical practice a few years later.',2 Its many advantages, such as quick action, easy administration, non-explosiveness, high potency and low cost, led to its widespread use within a short time. Although initial animal work did not indicate any hepatotoxic effect,3`5 the first cases of unexplained hepatitis after exposure...

BACKGROUND Classically, the first plane of anesthesia is known as the stage of analgesia. Nonetheless, clinical evidence suggests that low doses of inhaled agents might enhance pain perception. The present experiments test the hypothesis that low concentrations of halothane increase response to a noxious thermal stimulus and attenuate the antinociceptive effect of intraventricular morphine via ...

In order to evaluate the effect of an opioid antagonist on depressed intrinsic central vaso-motor drive (carotid sinus reflex) and high voltage slow delta waves in the EEG associated with halothane, naloxone was injected intravenously in a bolus of 100 or 200 micrograms.kg-1 on different days in the anaesthetized dog (0.64 Vol% halothane in oxygen). Only the 200 micrograms.kg-1 dose of naloxone...

Anaesthetic agents and doses used can significantly impact cerebrocortical responsiveness as assessed by electroencephalography (EEG). The objective of this study was to evaluate the effect three different halothane concentrations on EEG Rock Doves using measures frequency distribution burst suppression. Eight healthy (Columba livia) were anaesthetized with in oxygen, their tracheas intubated l...