in this study we investigate voice productions of normal speakers and patients with varying vocal fold adduction deficiencies using a noninvasive method to measure spatial vibrations of the larynx. the current version accv4 of our acceleration sensor device was used. The study’s primary goal is to find out whether lesions of vocal folds lead to additional spatial vibration modes compared to a n...

The common approach for constructing a classifier particle selection assumes reasonable consistency between train data samples and the target sample used particular analysis. However, may have very different properties, like energy spectra signal background contributions. We propose new method based on an ensemble of pre-trained classifiers, each trained exclusive subset, basket, total dataset....

BACKGROUND It has been suggested that Human endogenous retroviruses (HERVs) are associated with multiple sclerosis (MS) pathogenesis. The objective of this study was to broadly evaluate the expression of HERV core (GAG) and envelope (ENV) genes in diseased brain white matter samples from MS patients compared to normal controls. METHODS Twenty-eight HERV GAG and 88 ENV gene sequences were retr...

Rational peptide design and large-scale prediction of peptide structure from sequence remain a challenge for chemical biologists. We present PEP-FOLD, an online service, aimed at de novo modelling of 3D conformations for peptides between 9 and 25 amino acids in aqueous solution. Using a hidden Markov model-derived structural alphabet (SA) of 27 four-residue letters, PEP-FOLD first predicts the ...

Twin studies have demonstrated overlap between genetic contributions to posttraumatic stress disorder (PTSD) and other psychiatric disorders.1 These findings have prompted interest in examining shared genetic risk between PTSD and other psychopathology at the molecular level. With genome-wide association studies (GWAS) and collaborative consortia-based efforts, replicable risk variants have bee...

Biological responses often obey Weber's law, according to which the magnitude of the response depends only on the fold change in the external input. In this study, we demonstrate that a system involving a simple autocatalytic reaction shows such a response when a chemical is slowly synthesized by the reaction from a faster influx process. We also show that an autocatalytic reaction process occu...

The well-known third list homomorphism theorem states that if a function h is both an instance of foldr and foldl , it is a list homomorphism. Plenty of previous works devoted to constructing list homomorphisms, however, overlook the fact that proving h is both a foldr and a foldl is often the hardest part which, once done, already provides a useful hint about what the resulting list homomorphi...

The CCAAT box is one of the most common cis-elements present in eukaryotic promoters and is bound by the transcription factor NUCLEAR FACTOR Y (NF-Y). NF-Y is composed of three subunits, NF-YA, NF-YB, and NF-YC. Unlike animals and fungi, plants have significantly expanded the number of genes encoding NF-Y subunits. We provide a comprehensive classification of NF-Y genes, with a separation of cl...

We have shown previously that fibrin(ogen) binds fibroblast growth factor 2 (FGF-2) and potentiates stimulation of endothelial-cell (EC) proliferation. We have now used 2 FGF-2 mutants differing only in the 5 residues constituting the binding site to characterize the importance of this interaction in angiogenesis. The nonbinding (2212) and binding (221*2) mutants stimulated EC proliferation by ...