BACKGROUND The Autotransporter pathway, ubiquitous in Gram-negative bacteria, allows the efficient secretion of large passenger proteins via a relatively simple mechanism. Capitalizing on its crystal structure, we have engineered the Escherichia coli autotransporter Hemoglobin protease (Hbp) into a versatile platform for secretion and surface display of multiple heterologous proteins in one car...

Streptococcal toxic shock syndrome (STSS) caused by Streptococcus pyogenes is a clinical condition with a high mortality rate despite modern intensive care. A key feature of STSS is excessive plasma leakage leading to hypovolemic hypotension, disturbed microcirculation and multiorgan failure. Previous work has identified a virulence mechanism in STSS where M1 protein of S. pyogenes forms comple...

Right ventricular (RV) pacing has been reported to result in ventricular dyssynchrony, heart failure, and increased mortality. Pacing associated deterioration of left ventricular (LV) systolic function has been termed pacing-induced cardiomyopathy (PICM). While upgrading to biventricular pacing (BiVP) is an effective therapy for PICM, permanent His-bundle pacing (HBP) can be a physiological alt...

ABSTRACT Gymnogeophagus labiatus and G. lacustris have been long recognized as sister species exhibiting different ecological requirements. occurs in rock bottom rivers the hydrographic basins of Patos Lagoon (HBP) Tramandaí River (HBT), while is exclusive from sand coastal lagoons HBT. In this study, we used molecular markers, morphological measurements data nuptial male coloration to investig...

The BioMediator system developed at the University of Washington (UW) provides a theoretical and practical foundation for data integration across diverse biomedical research domains and various data types. In this paper we demonstrate the generalizability of its architecture through its application to the UW Human Brain Project (HBP) for understanding language organization in the brain. We firs...

The loss probability of bursts in an optical burst switching (OBS) network tends to be proportional to the number of hops between the burst’s ingress and egress switches because no buffers are implemented for the data bursts at the core switches. This causes unfairness for multi-hop bursts. We propose a preemption scheme, called hop based preemption (HBP), in order to resolve the unfairness iss...

Introduction Cardiac resynchronization therapy (CRT) achieved by implanting a lead via the coronary sinus (CS) system significantly improves well-being, symptoms, morbidity, and mortality in appropriately selected populations with advanced heart failure (HF) or pacing-induced cardiomyopathy. Despite improvements in implant technique, lead design, and pacing algorithms, there still remains a sig...

Objective: The aim of the present study was to estimate prevalence high blood pressure in schoolchildren aged 4-14 years from urban peripheral areas city La Plata, and analyze variations by sex, age, excess weight family socioeconomic status. Materials methods: Systolic diastolic pressure, body height were measured 3,312 both sexes. (HBP), overweight obesity calculated. Socioeconomic informatio...

BACKGROUND The purpose of this study was to evaluate the utility of bellows-based respiratory compensation and navigated hepatobiliary phase imaging to correct for respiratory motion in the setting of dedicated liver PET/MRI. METHODS Institutional review board approval and informed consent were obtained. Six patients with metastatic neuroendocrine tumor were imaged using Ga-68 DOTA-TOC PET/MR...

UNLABELLED Many hypertensive patients affected by endogenous Cushing's syndrome (CS) persist with high blood pressure (HBP) despite good control of cortisol excess. We assessed the effect of preoperative ketoconazole administration and of definitive treatment of CS on arterial hypertension and analysed the factors involved in the persistence of hypertension. We assessed retrospectively 71 patie...