background: there is a controversy about the relation between anti-hepatitis b (anti-hbs) antibody level and obesity. we designed this study to compare the vaccine efficacy in obese/overweight and non-obese cases. methods: in this cross-sectional study, 242 obese/overweight and 85 non-obese individuals were participated. cases were selected from a referral clinic for obesity and a referral hepa...

BACKGROUND The capacity of toll-like receptor (TLR) 7/8 agonist-conjugated hepatitis B virus (HBV) proteins (HBV-Ag) to overcome established hepatitis B surface antigen (HBsAg)-specific immune tolerance was explored. METHODS A TLR7/8 agonist, CL097, was conjugated with alum-absorbed HBsAg and hepatitis B core antigen (HBcAg), as confirmed by ultra performance liquid chromatography quadrupole ...

The study aimed to determine the association of additional N-glycosylation mutations in the major hydrophilic region (MHR) of hepatitis B virus (HBV) S gene with hepatocellular carcinoma (HCC) occurrence in HBsAg/anti-HBs coexistent patients. A total of 288 HBsAg/anti-HBs coexistent patients and 490 single HBsAg-positive patients were enrolled, including 193 with HCC, 433 with chronic hepatitis...

Background: Few studies have assessed long term persisting immunity against hepatitis B virus (HBV) in children vaccinated during infancy with combined vaccines containing recombinant HBV surface antigen (HBs). We assessed antibody persistence and immune memory in children 4-5 years of age, previously vaccinated with four doses of combined hexavalent DTPa-HBV-IPV/Hib vaccine (Infanrix hexaTM). ...

BACKGROUND Hepatitis B vaccination is recommended for health care workers but has a nonresponse rate of 5% to 32% and an unknown duration of immunity. There is no standardized postvaccination protocol to confirm, monitor, and maintain immunity. OBJECTIVE To assess the hepatitis B serologic immune status in health care workers who were previously vaccinated. METHODS A convenience survey and ...

OBJECTIVE To evaluate the efficacy of hepatitis B virus (HBV) vaccine in susceptible spouses at the time of marriage. METHODS From April 2003 to December 2005, 60 cases of susceptible wives of infected husbands and 32 cases of susceptible husbands of the infected wives in Babol north of Iran, received recombinant hepatitis B (HB) vaccine at the time of marriage followed with the second and th...

The changes in lgG antibody levels to hepatitis B surface antigen (HBsAg) and in antibody to HBsAg (anti-HBs) seroconversion rates due to different dosages of hepatitis B vaccine (HepB) were compared in 2106 children. Children who had been previously vaccinated as infants with HepB were revaccinated at 5-15 y of age, after which the antibody titers were determined. After the first booster dose,...

The purpose of this study was to determine the age wise prevalence of Hepatitis B virus (HBV) in children under five years and to analyze the relative importance of horizontal or vertical transmission. This study included 400 children in the age group of less than five years attending the outpatient department of pediatrics with minor complaints. History of HBV immunization was taken as the exc...

BACKGROUND Few studies have assessed long term persisting immunity against hepatitis B virus (HBV) in children vaccinated during infancy with combined vaccines containing recombinant HBV surface antigen (HBs). We assessed antibody persistence and immune memory in children 4-5 years of age, previously vaccinated with four doses of combined hexavalent DTPa-HBV-IPV/Hib vaccine (Infanrix hexa). M...

<b><i>Background:</i></b> Chronicity or seroclearance of hepatitis B virus (HBV) antigens is determined by the host immune responses. Current approaches to treat HBV patients are based on inhibition replication using different antivirals (nucleoside nucleotide analogs) as monotherapy, along with modulators combination therapy being used worldwide for reducing viral load....