Hydroxyurea (HU) can increase fetal hemoglobin (HbF) in kg. All four quartiles had substantial increases of F cells in sickle cell anemia (HbSS). To identify determinants of the the first year. This was maintained for 2 years only in the top HbF response, we studied 150 HU-treated patients grouped three quartiles. Leukocyte and reticulocyte counts decreased by quartiles of change in HbF from ba...

Pulmonary arterial hypertension (PAH) is emerging as a major complication and independent risk factor for death among adults with sickle cell disease (SCD). Using surface-enhanced laser desorption/ionization time of flight mass spectrometry (SELDI-TOF MS), we searched for biomarkers of PAH in plasma specimens from 27 homozygous sickle cell anemia (HbSS) patients with PAH and 28 without PAH. In ...

In this paper, we investigate the use of stochastic variable and value ordering heuristics for solving job shop scheduling problems with non-relaxable deadlines and complex metric constraints. Previous research in constraint satisfaction scheduling has developed highly effective, deterministic heuristics for this class of problems based on simple measures of temporal sequencing exibility. Howev...

BACKGROUND Renal involvement in sickle cell disease (SCD) contributes significantly to morbidity and mortality. The aim of this study was to determine the prevalence of chronic kidney disease (CKD) amongst SCD patients, and how basic clinical variables differ across haemoglobin genotypes. METHODS A hospital-based cross-sectional study conducted from December 2013 to May 2014 at the Sickle cel...

Pregnancy in sickle cell disease (SCD) patients is associated with increased risk of maternal and fetal mortality. This study determines pregnancy outcomes among women with SCD delivering at Korle-Bu Teaching Hospital, Accra, Ghana. Nine hundred sixty (960) medical records of pregnant women (131 HbSS, 112 HbSC, and 717 comparison group) from 2007 to 2008 were reviewed. The HbSS women were at in...

OBJECTIVE The DAta Food NEtworking (DAFNE) initiative was conceived in the 1980s and aims at using data already collected in the context of household budget surveys (HBSs) for the assessment of dietary patterns across Europe. DESIGN HBSs are country-representative surveys conducted, with similar methodology, at regular time intervals by the National Statistical Offices of almost all European ...

The aqueous leaf extracts of Basella alba were investigated in the present study for their in-vitro effect on red blood cell fragility in clinically confirmed HbSS subjects. A total of 12 human subjects, six (6) male and six (6) female with HbSS were used for this study. In-vitro osmotic fragility was determined spectrophotometrically by obtaining optical density at wavelength of 540nm. 5-6 ml ...

Hydroxyurea (HU) can increase fetal hemoglobin (HbF) in sickle cell anemia (HbSS). To identify determinants of the HbF response, we studied 150 HU-treated patients grouped by quartiles of change in HbF from baseline to 2 years. Half of the HU-assigned patients had long-term increments in HbF. In the top two quartiles, HbF increased to 18.1% and 8.8%. These patients had the highest baseline neut...

BACKGROUND Abnormal haemoglobin variants (HbSS,AS,AC,SC,etc) have been known to be common among blacks. Patients with sickle cell disease are often faced with the risk of alloimmunization from allogeneic blood transfusion. OBJECTIVES The study was designed to sample students population of African descents for the purpose of updating information on the prevalence of abnormal haemoglobin varian...

In sickle cell disease (SCD), hydroxyurea (HU) treatment decreases the number of vaso-occlusive crisis (VOC) and acute chest syndrome (ACS) by increasing fetal hemoglobin (HbF). Data are lacking regarding the frequency of HU dose modification or whether sub-therapeutic doses (<15 mg/kg/day) are beneficial. We reviewed the medical records of 140 patients from 2010 to 2014. The laboratory paramet...