PURPOSE In spite of the success of hepatitis B immunization, still a significant proportion of childhood hepatocellular carcinoma (HCC) failed to be prevented by the hepatitis B immunization program. This study is aimed to investigate the problems in the HCC prevention in children. EXPERIMENTAL DESIGN All HCC children ages 6 to 14 diagnosed between 1981 and 2000 in Taiwan were collected from ...

BACKGROUND Increasing evidence supports the association of CTNND1 with tumor development and progression. However, the mechanism and clinical significance of CTNND1 deregulation in hepatocellular carcinoma (HCC) remains unknown. In this study, we aim to investigate the role of CTNND1 in HCC. METHODS qRT-PCR and immunohistochemical analyses were used to measure the levels of CTNND1 in HCC spec...

It has come to our attention that the excel files of following supplementary tables were not included during online publication article: Table S3, S4, S8, S9, S13, and S14. These have now been made available online. We apologize for any inconvenience caused. Molecular characterisation hepatocellular carcinoma in patients with non-alcoholic steatohepatitisJournal HepatologyVol. 75Issue 4PreviewN...

Hepatitis B virus (HBV) genotypes/subgenotypes and their related mutations in the HBV genome have been reported to be associated with hepatocellular carcinoma (HCC). To determine the HCC-associated mutations of the HBV genome in the entire X, core promoter, and precore/core regions, a cross-sectional control study was conducted comparing 80 Japanese patients infected with HBV C2 and suffering f...

AIM To screen novel markers for hepatocellular carcinoma (HCC) by a combination of expression profile, interaction network analysis and clinical validation. METHODS HCC significant molecules which are differentially expressed or had genetic variations in HCC tissues were obtained from five existing HCC related databases (OncoDB.HCC, HCC.net, dbHCCvar, EHCO and Liverome). Then, the protein-pro...

HYPOTHESIS Transarterial chemoembolization (TACE) is beneficial for selected patients with unresectable hepatocellular carcinoma (HCC). DESIGN AND SETTING A prospective comparison study in a tertiary hospital. STUDY PERIOD November 21, 1995, to May 2, 2001, with a mean follow-up of 939 days. PATIENTS A total of 157 TACE treatments were performed in 88 patients with unresectable HCC: 132 t...

AIM Hepatocellular carcinoma (HCC) is a common disease in Taiwan. The prevalence of viral hepatitis infection and the subsequent development of HCC are well known to be higher in patients with end-stage renal disease (ESRD) requiring hemodialysis (HD) or peritoneal dialysis (PD) than among the general population. However, information on hepatic resection for ESRD-HCC patients is limited. METH...

Abstract Background The study aimed to establish a 68 Ga-FAPI-04 kinetic model in hepatic lesions, determine the potential role of parameters differentiation hepatocellular carcinoma (HCC) from non-HCC lesions. Material and methods Time activity curves (TACs) were extracted seven HCC lesions five obtained dynamic positron emission tomography (PET) scans eight patients. Three models applied TACs...

Abstract Chronic Infection of Hepatitis B virus (HBV) is one risk factor hepatocellular carcinoma (HCC). Much effort has been made to research the process HBV-associated HCC, but its molecular mechanisms carcinogenesis remain vague. Here, weighted gene co-expression network analysis (WGCNA) was employed explore co-expressed modules and hub/key genes correlated HCC. We found that most significan...