The cellular sites and mechanisms of human cytomegalovirus (HCMV) latency are still poorly defined. Although evidence suggests that peripheral blood monocytes are one site of latency in the healthy carrier, it is unlikely that monocytes represent a site of primary HCMV infection. Consequently, we have analysed CD34+ bone marrow progenitors, precursors of monocytes, to determine whether they are...

Amaç: İmmünsüprese hastalarda fırsatçı enfeksiyonun yaygın patojenleri olan İnsan Sitomegalovirüs (HCMV) ve Epstein-Barr virüsün (EBV) immünokompetan konakçıda yeniden aktivasyonu genellikle asemptomatiktir, ancak kronik hastalığa neden HBV gibi virüslerle koenfeksiyonu hastalığın prognozunu kötü etkileyebilir. Bu çalışmada histolojik aktivite indeksi bilinen hastalarında HCMV/EBV enfeksiyon pr...

Members of the Herpesviridae family have been implicated in a number of tumours in humans. At least 75% of the human population has had contact with cytomegalovirus (HCMV). In this work, we screened 75 Brazilian glioma biopsies for the presence of HCMV DNA sequences. HCMV DNA was detected in 36% (27/75) of the biopsies. It is possible that HCMV could be a co-factor in the evolution of brain tum...

Human cytomegalovirus (HCMV) infects a large percentage of humans worldwide [1]. In most individuals, HCMV establishes a largely asymptomatic latent infection. It can, however, lead to serious disease in immunocompromised individuals, and HCMV infection of the fetus is a common cause of congenital defects. Because it produces relatively few symptoms, HCMV latency was largely thought to be quies...

We conducted a survey of human cytomegalovirus (HCMV) genotypes among 176 children aged 1 month to 5 years living at Phayathai Babies' Home in Nonthaburi Province, Thailand to determine the prevalence of HCMV glycoprotein B (gB) genotype. The study was conducted on urine samples using nested polymerase chain reaction and restriction fragment length polymorphism; the HCMV gB1 genotype was found ...

The effect of abrogating the interferon (IFN) response on human cytomegalovirus (HCMV) replication was investigated using primary human cells engineered to block either the production of or the response to type I IFNs. In IFN-deficient cells, HCMV produced larger plaques and spread and replicated more rapidly than in parental cells. These cells demonstrate the vital role of IFNs in controlling ...

UNLABELLED Congenital human cytomegalovirus (HCMV) infection is a leading cause of birth defects, primarily manifesting as neurological disorders. HCMV infection alters expression of cellular microRNAs (miRs) and induces cell cycle arrest, which in turn modifies the cellular environment to favor virus replication. Previous observations found that HCMV infection reduces miR-21 expression in neur...

Received: 25 June 2008 Accepted: 19 November 2008 Abstract: Objective: Recent studies have demonstrated that various human viruses, especially cytomegalovirus (HCMV) and Epstein Barr virus (EBV-1) seem to play a part in the pathogenesis of human periodontitis. The aim of this investigation was to evaluate the subgingival presence of HCMV and EBV in patients with aggressive periodontitis (AgP). ...

Diagnosis of primary human cytomegalovirus (HCMV) infection is accomplished exclusively by serologic testing. Among the possible methods, the determination of immunoglobulin G (IgG) avidity is one of the least explored. In this work, we used a commercially available kit to test anti-HCMV IgG avidity in 336 serum samples from pregnant women and transplant recipients undergoing virologically prov...

Delayed elimination of human cytomegalovirus (HCMV)-infected cells by the host immune system may contribute to viral dissemination and pathogenesis of HCMV infection. The mRNA expression dynamics of HCMV-encoded immune evasion genes US3, US6, and US11 expressed after active HCMV infection were analyzed in blood samples of lung transplant recipients by means of quantitative nucleic acid sequence...