Heart regeneration is limited in adult mammals but occurs naturally in adult zebrafish through the activation of cardiomyocyte division. Several components of the cardiac injury microenvironment have been identified, yet no factor on its own is known to stimulate overt myocardial hyperplasia in a mature, uninjured animal. In this study, we find evidence that Neuregulin1 (Nrg1), previously shown...

BACKGROUND We previously reported that adult female, but not male rats that were prenatally exposed to methamphetamine exhibit myocardial hypersensitivity to ischemic injury. However, it is unknown whether hypersensitivity to ischemic injury develops when rats are exposed to methamphetamine during adulthood. The goal of this study was to determine whether methamphetamine exposure during adultho...

QUESTIONS UNDER STUDY To evaluate the diagnostic value of serum Cystatin C and urine neutrophil gelatinase-associated lipocalin (NGAL) for the detection of acute kidney injury in patients undergoing congenital heart surgery. METHODS Serial samples of serum Cystatin C and urine NGAL were collected from 139 consecutive patients with congenital heart defects aged 3 days to 30 years after admissi...

Myocardial inflammation, COVID-19, and HFpEF inflammation is widely considered to be one of the main factors in development heart failure (HF). It believed that persistent myocardial plays a central role adverse left ventricular remodeling after infarction, as well pathogenesis dilated cardiomyopathy with preserved ejection fraction (HFpEF). – In May 2020, Tavazzi et al. reported first case acu...

(Abstracted from N Engl J Med 2022;386:1781–1792) Chronic hypertension affects >2% of pregnancies in the United States and disproportionately Black women. The condition is also associated with an increased risk adverse neonatal outcomes, including preeclampsia, placental abruption, preterm birth, small for gestational age (SGA), or perinatal death, maternal heart failure, stroke, pulmonary edem...

Hridaya (heart) is considered as one of the vital organ body by Ayurveda. Since it among Trimarams and regarded Dasha prana ayatana, any injury to results in causation grave diseases, severe complications or even death. A vigilant study reveals that, two organs share approximately equal claims put themselves identical with term which denotes an controlling passage Prana collecting, distributing...

Volatile anesthetic agents have been used for decades in the peri-operative setting. Data from the past 15 years have shown that pre-injury administration of volatile anesthetic can decrease the impact of ischemia-reperfusion injury on the heart, brain, and kidney. Recent data demonstrated that volatile agents administered shortly after injury can decrease the ischemia-reperfusion injury. Sever...