BACKGROUND/AIMS The sensitivity of the upper and lower esophageal mucosa to acid is considered to differ. We investigated the relationship between pH changes in different sites of the esophagus and generation of gastroesophageal reflux symptoms during an acid infusion test. METHODS An acid infusion catheter was placed at 5 or 15 cm above the lower esophageal sphincter (LES) in 18 healthy volu...

Reflux gastroesophagitis is a common postgastrectomy complication after proximal gastrectomy, and conservative treatments including protease inhibitors and proton pump inhibitors are effective in most patients. Here we report a patient with severe reflux gastroesophagitis after proximal gastrectomy, in whom surgical treatment of duodenal switch was effective. An 80-year-old man complained of in...

Introduction: Ineffective esophageal motility (IEM) is an disorder (EMD) and the most prevalent abnormality routinely observed in manometry. Objectives: In this study, we investigated clinical characteristics of IEM patients effects proton pump inhibitors (PPI) surgical treatments on their conditions. Patients Methods: This cross-sectional study was conducted Isfahan 2019-2020 40 diagnosed with...

Dyspepsia, according to the internationally accepted Rome criteria, refers to pain or discomfort centred in the upper abdomen; patients with predominant heartburn are excluded from this group, although minor or infrequent heartburn is commonly associated with dyspepsia. It is an important condition not only because it is common and costly, but because it may indicate the presence of serious dis...