Repeated oral administration of mexazolam, an anti-anxiety agent, may cause adverse effects such as gastric disturbance, drowsiness, and ataxia due to transiently high blood levels. Transdermal administration would avoid the systemic side effects and gastric disorders after oral administration. We have developed a matrix using ethylene-vinyl acetate (EVA), a heat-processible and flexible mat...

in the present work, multidimensional modeling of open-cycle process of om355 engine was developed. calculations for computational mesh were carried out. the results of the model were validated by experimentally measured in-cylinder pressure and the good agreement between calculations and measurements approved the trustworthy of numerical code. results included pressure, temperature, emission a...

BACKGROUND In this study, the putative interactions between apoptosis and heat shock proteins disturbed as a result of ATP depletion were investigated as a hypoxia model. METHODS The direct cellular damages were assessed by the release of LDH from the cytoplasm of the human tubular epithelial cells (HK-2 cells) following ATP depletion. The Bcl-2/Bax mRNA expression ratio, used as an index to ...

Cylinder deactivation (CDA) is a technology that can improve the fuel economy and exhaust thermal management of compression ignition engines (diesel and natural gas), especially at low loads and engine idling conditions. The reduction in engine displacement during CDA improves fuel efficiency at low loads primarily through a reduction in pumping work. During deactivation of a given cylinder, th...

Consequent to a big arson fire in a karaoke establishment, a new Karaoke Establishments Bill is to be implemented for providing a safer indoor environment for karaoke activities. There, a long list of fire safety provisions is specified. There are concerns from the local industry as it has not been demonstrated that following the new requirements will ensure fire safety. Building refurbishment ...

In the present work, multidimensional modeling of open-cycle process of OM355 engine was developed. Calculations for computational mesh were carried out. The results of the model were validated by experimentally measured in-cylinder pressure and the good agreement between calculations and measurements approved the trustworthy of numerical code. Results included pressure, temperature, emissi...

Toxoplasma gondii tachyzoites markedly alter the profile of eicosanoids released by human mononuclear phagocytes. Freshly isolated, 2-h adherent human monocytes release both cyclooxygenase (e.g., thromboxane [TX] B2, prostaglandin [PG] E2) and 5-lipoxygenase (e.g., leukotriene [LT] B4, LTC4) products of arachidonic acid metabolism after stimulation by the calcium ionophore A23187 or ingestion o...

The cone calorimeter is considered the most significant bench scale instrument in fire testing. This apparatus has been adopted by the International Organization for Standardization (ISO 5660-1) for measuring heat release rate (HRR) of a sample. It has been shown that most fuels generate approximately 13.1 MJ of energy per kg of oxygen consumed. Therefore, HRR is based on the fact that the oxyg...

Populations of Bacillus subtilis spores in which 90 to 99.9% of the spores had been killed by moist heat gave only two fractions on equilibrium density gradient centrifugation: a fraction comprised of less dense spores that had lost their dipicolinic acid (DPA), undergone significant protein denaturation, and were all dead and a fraction with the same higher density as that of unheated spores. ...

Hot beverages such as tea, hot chocolate, and coffee are frequently served at temperatures between 160 degrees F (71.1 degrees C) and 185 degrees F (85 degrees C). Brief exposures to liquids in this temperature range can cause significant scald burns. However, hot beverages must be served at a temperature that is high enough to provide a satisfactory sensation to the consumer. This paper presen...