ot all isoforms are created equal. New results from Christiana Ruhrberg, David Shima (Cancer Research UK, London, UK), and colleagues reveal that the stickiness of vascular endothelial growth factor (VEGF) can make all the difference between blood vessels growing larger or finding new territory. VEGF initiates the formation and expansion of the vascular system. VEGF isoforms differ in their abi...

Increased susceptibility to genital herpes in medroxyprogesterone-treated mice may provide a surrogate of increased HIV risk and a preclinical biomarker of topical preexposure prophylaxis safety. We evaluated tenofovir disoproxil fumarate (TDF) in this murine model because an intravaginal ring eluting this drug is being advanced into clinical trials. To avoid the complications of surgically ins...

This paper firstly described the dam break in the aspects of theories and models. Break parameters prediction, the understanding of dam break mechanics, peak outflow prediction were shown as the essential for the dam break analysis, and eventually determined the loss of the damages. Secondly, as an application example, Foster Joseph Sayers Dam break was further modeled and analyzed using USACE ...

Estrogen receptor-related receptor α (ERRα) has been identified as a nuclear transfactor closely related to estrogen receptor α (ERα). ERRα interferes with ER-mediated signaling pathways through competition with ERα for the common DNA sites and coregulators. Thus, it may participate in the tumorigenesis of estrogen-related cancers. To elucidate the roles of ERRα in endometrial carcinogenesis an...

PURPOSE Chemotherapy-induced nausea and vomiting (CINV) are major adverse effects of cancer chemotherapy. We compared the impact of acute (during the first 24 hours postchemotherapy) and delayed (days 2 through 5 postchemotherapy) CINV on patients' quality of life (QoL) after highly or moderately emetogenic chemotherapy (HEC and MEC, respectively). PATIENTS AND METHODS This prospective, multi...

The aim of this study was to characterize the swelling and floating behaviors of gastroretentive drug delivery system (GRDDS) composed of hydroxyethyl cellulose (HEC) and sodium carboxymethyl cellulose (NaCMC) and to optimize HEC/NaCMC GRDDS to incorporate three model drugs with different solubilities (metformin, ciprofloxacin, and esomeprazole). Various ratios of NaCMC to HEC were formulated, ...

In this study, Fe(II) complexes of phenyldithiocarbamate, dimethyldithiocarbamate and imidazolyldithiocarbamate were used as single-source precursors to prepare iron sulphide nanoparticles by thermolysis in oleic acid/octadecylamine (ODA) at 180 °C. The nanoparticles were dispersed into hydroxyethyl cellulose (HEC) to prepare iron sulphide/HEC nanocomposites. Ultraviolet-Visible (UV-Vis), Photo...

Granisetron and other 5-hydroxytryptamine type 3 (5-HT3) receptor antagonists are first-line agents for preventing chemotherapy-induced nausea and vomiting (CINV). Current treatment guidelines prefer the longer-acting agent, palonosetron, for CINV prevention in some chemotherapy regimens. A new granisetron formulation, APF530, has been developed as an alternative long-acting agent. APF530 utili...

PURPOSE Angiotensin (Ang) II was reported to induce vascular endothelial growth factor (VEGF) expression in various cells. Adipocyte-derived leucine aminopeptidase (A-LAP) is a novel member of the M1 family of zinc metallopeptidases. Enzymatic characterization demonstrated that A-LAP hydrolyzes Ang II. This study examined the role of A-LAP in angiogenesis of human endometrial carcinoma. EXPER...

Mucoadhesive gels were prepared for the treatment of oral sub mucous fibrosis, which provide effect for extended periods of time. Stress was given for improvised local action of the drug with the addition of mucoadhesive polymer in the formulation. Curcumin was taken as a model drug as it exhibits profound antitumeric & antimutogenic activity. The semisolid preparations comprised of stabilizer ...