RATIONALE Platelets are anuclear cell fragments derived from bone marrow megakaryocytes (MKs) that safeguard vascular integrity but may also cause pathological vessel occlusion. One major pathway of platelet activation is triggered by 2 receptors that signal through an (hem)immunoreceptor tyrosine-based activation motif (ITAM), the activating collagen receptor glycoprotein (GP) VI and the C-typ...

We greatly thank the authors of this letter for pointing out the significance of our original contribution of the hierarchical error model (HEM) in Cho and Lee (2004). As the authors suggested, we agree that an extension of HEM can be made for gene expression data with biological and/or experimental correlations. However, we here discuss several issues in response to some of the points raised i...

Fifty-five observations were used to determine the ME content of 8 foods containing different protein sources. The major protein sources tested included low-oligosaccharide whole soybeans; 2 low-oligosaccharide, low-phytate whole soybeans; 2 conventional soybean meals; low-ash poultry meal; low-oligosaccharide, low-phytate soybean meal; and conventional whole soybeans. The ME content of all foo...

objective(s) the aim of this study was to evaluate the expressions of two angiogenic immune-markers (cd-31 and vegf), and one proliferative immune-marker (ki-67) in oral pyogenic granulomas (pg), hemangiomas (hem) and inflammatory gingivitis (ig). materials and methods sixty cases of pg, hem and ig (twenty cases each) were examined. immunohistochemical (ihc) staining was performed based on rout...

Cajal-Retzius (CR) cells of the developing neocortex secrete Reelin (Reln), a glycoprotein involved in neuronal migration. CR cells selectively express p73, a p53 family member implicated in cell survival and apoptosis. Immunocytochemistry in prenatal human telencephalon reveals a complex sequence of migration waves of p73- and Reln-immunoreactive (IR) neurons into the cortical marginal zone (M...

The aim of this study was to determine the apoptotic effects, toxicity, and radiosensitization of total low dose irradiation delivered at a high dose rate in vitro to melanoma cells, normal human epidermal melanocytes (HEM), or normal human dermal fibroblasts (HDF) and to study the effect of mitochondrial inhibition in combination with radiation to enhance apoptosis in melanoma cells. Cells irr...

In this research we experimented with a new and rapid way of analyzing wood. Near Infrared (NIR) spectroscopy together with multivariate analysis is becoming a widely used technique in the field of forest products especially for property determination and is already firmly established in the pulp and paper industry. This method is ideal for the chemical analysis of wood, and therefore preservat...

Burkholderia pseudomallei is a mostly saprophytic bacterium, but can infect humans where it causes the difficult-to-manage disease melioidosis. Even with proper diagnosis and prompt therapeutic interventions mortality rates still range from >20% in Northern Australia to over 40% in Thailand. Surprisingly little is yet known about how B. pseudomallei infects, invades and survives within its host...