Responses to exchange transfusion with red blood cells (RBCs) containing methemoglobin (MetRBC) were studied in an acute isovolemic hemodiluted hamster window chamber model to determine whether oxygen content participates in the regulation of systemic and microvascular conditions during extreme hemodilution. Two isovolemic hemodilution steps were performed with 6% dextran 70 kDa (Dex70) until s...

purpose: in this study the effect of iron supplmentation on hemoglobin and hematocrit in pregnant women with hb>13.2 g/dl was investigated. material and methods: in this experimental clincal study, the effect of iron supplementation on hemoglobin and hematocrit in pregnant women with hb>13.2 g/dl and ferritin> 14.3 μg/l during the 13th- 18th pregnancy week was studied. eighty seven women havin...

Objective: To discover and analyze the value of coagulant molecular marker in diagnosis of cerebral infarction after intracerebral hemorrhage. Methods: In this study, we selected a total of 42 patients with cerebral infarction after intracerebral hemorrhage as the experiment group; additionally, 42 patients with intracerebral hemorrhage were enrolled as the hemorrhage control group; besides, 42...

OBJECTIVE To determine if iron supplementation of 2 mg/kg per day, in addition to routine iron-fortified formula or mother's milk, increased the hematocrit (Hct) at 36 weeks' postmenstrual age (PMA). METHODS : Infants with a birth weight <1500 g who reached 120 mL/kg per day of feedings before 32 weeks' PMA were randomly assigned to iron (multivitamin with iron) or control (multivitamin) from...

INTRODUCTION Numerous testosterone (T) formulations are available, each with differing effects on serum parameters. AIM The aim of this study was to compare the long-term effects of topical, injectable, and implantable pellet T formulations in hypogonadal men. METHODS Retrospective review of hypogonadal men treated with a single T formulation was performed: 47 men on T gels, 57 on injectabl...

Methods 77 healthy volunteers with no known cardiovascular condition underwent CMR at 1.5T (Siemens, Avanto). Mid ventricular short axis native T1 maps by MOLLI (with T1* reconstruction in addition) and ShMOLLI were acquired. Hematocrit (Hct), iron profile and lipid profile were acquired immediately prior to the scan. CVI42 (Calgary, Canada) was used for analysis of the maps. A ROI was drawn in...

BACKGROUND Hemoconcentration has been proposed as surrogate for changes in volume status among patients hospitalized with acute heart failure (AHF) and is associated with a favorable outcome. However, there is a dearth of research assessing the clinical outcomes of hospitalized patients with hemoconcentration, hemodilution and unchanged volume status. METHODS We enrolled 510 consecutive patie...

BACKGROUND AND PURPOSE Because MR imaging is becoming integral to the evaluation and treatment of very early stroke, it is critical to prove that MR imaging is at least as sensitive to acute subarachnoid hemorrhage (SAH) as is CT. The present study was conducted to evaluate the possibility of detecting a small amount of acute SAH diluted by CSF not revealed by CT but identified on fluid-attenua...

Secondary erythrocytosis in cyanotic congenital heart disease (CCHD) is a compensatory response to chronic hypoxia which should be managed with caution. CCHD patients, who have compensated erythrocytosis but do not manifest significant neurologic symptoms, may experience secondary life-threatening complications such as stroke in case of inappropriate phlebotomy. This study reports a young man w...

Dried blood spots (DBS) in their current format encounter challenges in bioanalysis using fixed areas, including but not limited to, waste of DBS samples (only a fraction is used for analysis), the need for sample punching leading to concerns of sample carryover, uncertainty for accurate recovery assessments and hematocrit (HCT) effects. Here we describe a novel concept, namely perforated dried...