The aim of this multicenter GIMEMA study was to correlate autoimmune complications (AIC) in B-cell chronic lymphocytic leukemia (B-CLL) with stage and therapy. Autoimmune hemolytic anemia (129/194 cases) and autoimmune thrombocytopenia (35/194 cases) were typically present in advanced and multi-treated disease. Age over the median, stage C and first and second line therapy were identified as in...

There are literally dozens of distinct lymphoma subtypes, each with its own unique molecular and clinical features. Although systemic cytotoxic and targeted therapies have improved dramatically, radiation therapy remains an important modality for optimal clinical outcomes. With contributions from nationally recognized experts, Hematologic Malignancies offers an overview of the full spectrum of ...

Mild anemia and leukopenia are the most common hematologic problems of acute brucellosis. Mild thrombocytopenia also occurs, but severe cases are uncommon. Thrombocytopenia occurs because of bone marrow suppression, hypersplenisem, hemophagocytosis, and immunologic destruction of the cells or disseminated intravascular coagulation. In endemic areas, hemorrhagic fevers, hematologic malignancies,...

Pulmonary mucormycosis (PM) is a life-threatening fungal infection in patients with hematologic malignancies, and early and accurate diagnostic modalities are urgently needed. We conducted a polymerase chain reaction (PCR) assay targeting these fungi in peripheral blood from four patients with hematologic malignancies who were strongly suspected of having PM. In these four patients, the Rhizopu...

There are several distinct tools to identify orthologous gene sequence from homologous gene sequence. Identification of orthologous gene is a major issue, and it is found that orthologous genes are responsible for any genetic disorders. In this paper we are focusing on hematologic disorders and found that orthologous genes are primary actor of haematological disorders. Here we present a novel a...

The current Indochinese resettlement program in the United States has resulted in an increase in the number of persons with hemoglobin E trait. American physicians should be aware of the hematologic expressions of this innocuous condition. The hematologic manifestations of 21 persons with hemoglobin E trait were evaluated. The subjects were of Tai-dam, Vietnamese, Chinese, Laotian, and European...

background and purpose: invasive candidiasis (ic) is a significant cause of morbidity and mortality in patients with hematologic disorders and bone marrow transplant recipients. rapid, specific and sensitive test for the timely accuracy in immunocompromised patients to reduce mortality rates and prevent ic progress is necessary. we established a real-time pcr assay on blood for the diagnosis an...

BACKGROUND In patients bitten by North American rattlesnakes and treated with Crotalidae Polyvalent Immune Fab (Ovine) (FabAV), late hematologic abnormalities-persistent, recurrent, or late, new onset of hypofibrinogenemia, prolonged PT/INR, prolonged PTT, and/or thrombocytopenia beyond 48 h post-envenomation-are common, difficult to manage, and may result in morbidity and mortality are common,...

Purpose: PIMkinases have been shown to act as oncogenes inmice, with each familymember being able to drive progressionofhematologic cancers. Consistentwith this,we found that PIMs are highly expressed in human hematologic cancers and show that each isoform has a distinct expression pattern among disease subtypes. This suggests that inhibitors of all three PIMs would be effective in treating mul...

To diagnose acute myocardial infarction, selected cardiac markers as well as hematological and biochemical indices have been studied in human being, however, rare investigations were done on the values of hematologic analysis in an ovine model of myocardial infarction. To observe the change of the values in hematologic parameters in sheep, acute myocardial infarction was induced by ligation of ...