BACKGROUND EphA3 is a component of the Eph receptor family, the largest subgroup of the receptor tyrosine kinase (RTK) family. A recent array-based study implicated the presence of copy-number variations (CNVs) of EphA3 in the genomes of acute myelogenous leukemia. CNVs are present in the general population at varying degrees, and have been found to associate with various types of diseases incl...

INTRODUCTION In general, ocular complications of hematologic malignancies such as leukemia are well documented. However, reports of ocular involvement in such diseases as lymphomatoid granulomatosis and chronic myelomonocytic leukemia are uncommon. Here we present cases of these two relatively rare hematologic malignancies demonstrating clinical and subclinical ocular involvement. CASE PRESEN...

BACKGROUND Myelodysplastic syndromes (MDS) are clonal diseases of hematopoietic cells. The International Prognostic Scoring System (IPSS) is the risk scale most employed in MDS. Cyclosporin A (CsA) has been used in the treatment of cytopenias in MDS. OBJECTIVE To evaluate hematologic response and identify response predictive factors in adults with MDS treated with CsA. MATERIAL AND METHODS ...

Graft Versus Host Disease (GVHD) is a life threatening complication of allogeneic bone marrow transplantation (BMT), an important therapy for a number of hematologic diseases. In its acute phase, GVHD involves activation of proinflammatory cytokine cascades and immune effector cells that result in target tissue damage (1, 2). Multiple cellular populations and cytokines interact in a complex pro...

background: ovine anaplasmosis and theileriosis are important tick-borne diseases of sheep and goats which are distributed in the tropical and subtropical areas of the world. objectives: this study was performed to assess hematological status in sheep naturally infected with anaplasma and theileria spp. to clarify the pathogenic aspects of various species involved in ovine anaplasmosis and thei...

introduction: most of the hematologic malignancies are heterogenous with regard to morphology, immunophenotype, and genetic rearrangements. multiple recurrent chromosomal aberrations have been identified by conventional cytogenetic analysis, which is now widely recognized as one of the most important diagnostic and prognostic determinants in these patients. patients and methods: bone marrow sam...

To the Editor: Some hematologic markers, such as the neutrophil-tolymphocyte ratio (NLR), platelet-to-lymphocyte ratio, and mean platelet volume (MPV), have gained popularity as possible predictive factors in oncologic and nononcologic inflammatory processes [1-3]. We have read the letter about our recently published report, “Predictive Role of Hematologic Parameters in Testicular Torsion” [4]....

Telomeres are specific nucleoprotein structures at the ends of eukaryotic chromosomes. Telomeres and telomere-associated proteins maintain genome stability by protecting the ends of chromosomes from fusion and degradation. In normal somatic cells, the length of the telomeres gradually becomes shortened with cell division. In tumor cells, the shortening of telomeres length is accelerated under t...