1Department of Translational Hematology and Oncology Research, Taussig Cancer Center, Cleveland Clinic, Cleveland, OH; 2Division of Hematology and Hematological Malignancy, Departments of Medicine and Oncology, Johns Hopkins University School of Medicine, Baltimore, MD; 3Ronald Reagan UCLA Medical Center, Los Angeles, CA; and Departments of 4Clinical Pathology and 5Hematologic Oncology and Bloo...

Cerebral venous thrombosis (CVT) is a relatively rare cause of stroke and has a wide spectrum of unspecific symptoms, which may delay diagnosis. There are many etiologies, including hematological disorders, trauma, infection, and dehydration. Iron-deficiency anemia (IDA) has been reported as an extremely rare cause of CVT, especially in adults.

Bone marrow biopsy is a mandatory procedure to diagnose several hematological disorders. This invasive analysis is generally safe and the procedure-related risks are rare and include bleeding at the site of puncture and, very occasionally, local infections. Here, we describe a case of sacroiliitis that occurred as a consequence of bone marrow biopsy.

The beta thalassemia intermedia phenotype has several genotypes. Hematological and molecular diagnostic approach and logical and sequential conduct of various investigations are necessary for the diagnosis of these disorders. Close observations of the genotype-phenotype correlation will provide a better insight for the development of molecular therapy.

Besides cytopenia related to treatment, several hematological disorders such as anemia, abnormal platelet activity, thrombosis, presence of anticardiolipin or anti-neutrophil antibodies, cyclic neutropenia, and myelodysplasia, have been reported in patients with Crohn's disease (CD). The case we report here is the first one documenting the association of idiopathic thrombocytopenic purpura (ITP...

Angina bullosa hemorrhagica (ABH) is a benign disorder of the oral cavity. Clinically, oral, blood-filled blisters are seen. To give a proper diagnosis, one should rule out any other cause. We aim to present this case in order to emphasize this rare cause of oral bullae which is necessary to be differentiated from many serious dermatological and hematological disorders.

A case of a 53 year-old female patient who developed branch retinal vein occlusion after six 3 mg/kg Infliximab infusions for rheumatoid arthritis treatment is reported. Hematological disorders, cardiopathy and chronic systemic hypertension evaluation were negative. The relationship between the infliximab therapy and the development of retinal vein occlusion raises awareness of the possibility ...

We review the basic characteristics of four periodic hematological disorders (periodic auto-immune hemolytic anemia, cyclical thrombocytopenia, cyclical neutropenia and periodic chronic myelogenous leukemia) and examine the role that mathematical modeling and numerical simulations have played in our understanding of the origin of these diseases and in the regulation of hematopoiesis.

1Center for Immunotherapy of Cancer and Infectious Diseases, Department of Immunology, University of Connecticut School of Medicine, Farmington, CT; 2Department of Microbiology & Immunology, Medical University of South Carolina, Charleston, SC; 3Lea’s Foundation Center for Hematological Disorders, University of Connecticut School of Medicine, Farmington, CT; and 4Department of Pharmacology, Uni...

Many residents and fellows enter specialty training programs with vague notions as to what the clinical practice of their specialty will be like. Such speculation on the author’s part seems reasonable because the house staff is usually exposed to the specialty only in the hospital environment, and not in the private practitioner’s office. As well, there is little written information about the c...