Hematopoietic stem/progenitor cells (HSPCs) which give rise to different blood cell types are present within the bone marrow microenvironment, especially in flat bones such as skull, vertebrae, pelvis and chest. Interacting factors such as stromal derived factor-1/CXCR4, very late antigen-4/vascular cell adhesion molecule-1, Lymphocyte function-associated antigen-1/ intercellular adhesion molec...

currently, hematopoietic stem cell transplantation (hsct) is the only curative option for patients with beta-thalassemia major, but liver iron overload in these patients will not decrease and hepatic fibrosis may still progress despite successful hsct. liver biopsy samples were taken from 14 patients (out of 25 patients) who underwent hsct. all patients met three criteria: negative hcv antibody...

THE BRAZILIAN SOCIETY FOR BLOOD AND MARROW TRANSPLANTATION (SBTMO) PRESENTS GUIDELINES ON HEMATOPOIETIC STEM CELL

THE BRAZILIAN SOCIETY FOR BLOOD AND MARROW TRANSPLANTATION (SBTMO) PRESENTS GUIDELINES ON HEMATOPOIETIC STEM CELL

background nowadays, it has been found that the mental state of caregivers may have a noticeable effect on both patient and caregiver’s health. this study was conducted to determine the burnout and general health status of the hematopoietic stem cell transplantation nurses in tehran, iran. methods in a cross-sectional study, burnout and general health status of 65 hematopoietic stem cell transp...

background: marrow-derived mesenchymal stem cells (mscs) have been heralded as a source of great promise for the regeneration of the infarcted heart. there are no clear data as to whether or not in vitro differentiation of mscs into major myocardial cells can increase the beneficial effects of mscs. the aim of this study was to address this issue. methods: to induce mscs to transdifferentiate i...

thalassemia is an autosomal recessive disorder associated with defective synthesis of the α- or β-chain of hemoglobin. for β-thalassemia major patients, therapeutic options are either monthly red cell transfusions and chelation therapy or allogeneic stem cell transplant. stem cell transplant is the only curative approach and success is inversely correlated with the degree of iron overload and h...

The objective of the research was to determine effect educational intervention based on Bandura’s Social Cognitive Learning Theory care dependency and symptom management after hematopoietic stem cell transplantation.
 Methods. This randomized controlled trial conducted between January 2019 February 2020 at Hematopoietic Stem Cell Transplantation Center. All patients were randomly divided i...