Haemoglobin Kansas (Asn102(G4)/? + Thr) is the only widely studied mutant or modified haemoglobin having four functional haems and displaying lower than normal oxygen aBnity. Two forms of this mutant have been investigated by X-ray diffraction. The deoxy form, whose crystals are isomorphous with the native form, has been examined directly by the difference Fourier technique (3.4 A). In addition...

objectives: anemia is prevalent in heart failures and is an independent risk factor for adverse clinical outcomes in patients with chf. the aim of the present study was to determine the prevalence of anemia in elderly with systolic heart failure hospitalized in alborz hospital of karaj in 2009. methods & materials: this is a descriptive retrospective study that reviewed 154 medical records of e...

Dale and co-workers have reported on the influence of glycaemic control on long-term mortality from ischaemic heart disease (IHD) in patients with asymptomatic newly detected diabetes mellitus participating in a population-wide health survey in Norway. The annual measurements of glycated haemoglobin A1c (HbA1c) in subjects with newly diagnosed diabetes during the 10 years following recruitment ...

BACKGROUND The aim of this study was to determine the relationships between lens opacity, vascular and lipid factors and retrobulbar blood flow parameters in type-1 diabetic (DM) adolescents. MATERIAL/METHODS Glycated haemoglobin (HbA1c), total cholesterol (TCH), high- and low-density cholesterol, triglycerides (TG) and apolipoprotein B (ApoB) were determined in 28 patients with (DM-1) and wi...

PURPOSE Premixed insulin is effective to improve glycemic control; however, clinicians may be less likely to know which premixed insulin is appropriate for which patients. This study aimed to evaluate the effects of twice-daily injections of premixed insulin lispro on glycemic control in type 2 diabetic patients. MATERIALS AND METHODS Forty type 2 diabetic patients, who had been treated with ...

BACKGROUND Complications increase treatment costs of diabetes mellitus (DM). An adequate metabolic control of the disease could reduce these costs. AIM To evaluate the costs of medical care for a cohort of patients with DM, according to their degree of metabolic compensation. MATERIAL AND METHODS All diabetic patients attended in a regional hospital from 2005 to 2010 were analyzed. A correl...

OBJECTIVES To evaluate the impact of risk minimisation policies on the use of rosiglitazone-containing products and on glycaemic control among patients in Denmark and the UK. DESIGN, SETTING AND PARTICIPANTS We used population-based data from the Aarhus University Prescription Database (AUPD) in northern Denmark and from the General Practice Research Database (GPRD) in the UK. MAIN OUTCOME ...

Objective. To identify the number of haemodialysis patients with diabetes in a large NHS Trust, their current glycaemic control, and the impact on other renal specific outcomes. Design. Retrospective, observational, cross-sectional study. Methods. Data was collected from an electronic patient management system. Glycaemic control was assessed from HbA1c results that were then further adjusted fo...

OBJECTIVE The collaborative care model is recommended for depression in adults with a chronic physical health problem like diabetes. We sought to systematically assess the effect of collaborative care on depression and glycaemia in adults with comorbid depression and diabetes to inform guidelines and practice. DESIGN Systematic review and meta-analysis. DATA SOURCES We searched PubMed, Scop...

Glycation is the nonenzymatic addition of sugar to amino groups of proteins. While virtually any protein in the body can be glycated, for convenience and ease of obtaining a sample, glycated hemoglobin is measured in the blood obtained from a patient. Blood glucose concentrations exhibit wide diurnal fluctuations due to food ingestion, exercise, and other factors. In contrast, the concentration...