The hypotransferrinemic mouse (trf (hpx)) is a mutant strain exhibiting transferrin deficiency, marked anemia, hyperabsorption of iron, and elevated hepatic iron stores. We set out to investigate the relative roles of anemia and of transferrin in the malregulation of intestinal iron absorption in these animals. Transfusion of erythrocytes obtained from littermate controls increased hemoglobin l...

OBJECTIVE Hemorrhage still continues to be reported as one of the leading causes of maternal mortality and morbidity. Intraoperative estimation of the blood loss seems to be complex and misleading as it is impaired by the amount of amniotic fluid and blood from the placenta. The present study was aimed to investigate the safety of intraoperative deciding on an uneventful cesarean section in a l...

To diagnose iron deficiency in patients undergoing hemodialysis, the percentage of hypochromic RBCs (with cellular hemoglobin concentration <280 g/L [HYPO%]) and mean reticulocyte hemoglobin content (CHret) provided by the Siemens ADVIA 120 and 2120 analyzers (Siemens Diagnostic Solutions, Tarrytown, NY) were proposed as alternatives to biochemical tests. Sysmex, with its XE-5000 analyzer (Sysm...

type2 diabetic is a metabolic disease in which is associated with the relative or absolute insulin deficiency, elevated blood glucose and impaired metabolism of carbohydrates, fat and protein. since fat and exercise is important to improve glycemic control in diabetic patients, so the purpose of this study was to evaluate the effect of interval training on a cycle ergometer on insulin resistanc...

We studied glucose transport under physiological conditions (38 degrees C, pH 7.2, 5 mmol of glucose per liter) in erythrocytes of nine diabetic children with hemoglobin A1c values ranging from 6.6 to 13.8%, and in erythrocytes from six healthy children. Glucose transport was determined to be 2.38 (SD 0.16) X 10(-10) mol/cm2 X s (n = 18), and 2.47 (SD 0.18) X 10(-10) mol/cm2 X s (n = 12) in ery...

We report a case of a pregnant woman with a complex hemoglobinopathy who developed a symptomatic anemia at 28 weeks of gestation and was treated with multiple transfusions of type-specific packed red blood cells. Shortly thereafter, she developed a fever and joint pains, along with laboratory values consistent with hemolysis. Timing suggested a delayed transfusion reaction. An extensive evaluat...

This study evaluates the performance characteristics of the copper sulfate screening test in routine bloodmobile operations and compares the performance of the copper sulfate test with that of a miniphotometer method of hemoglobin measurement. The copper sulfate and miniphotometer tests provide equivalent pass/fail classification of male donors with a high sensitivity and total efficiency. For ...

BACKGROUND Glycation is known to play a key role in complications of many pathophysiological processes. The present study was carried out to assess whether there are abnormalities of non-enzymatic glycation of proteins and hemoglobin in acute Myocardial Infarction (MI) patients. METHODS Eighteen acute Myocardial Infarction (MI) patients and 20 healthy controls were enrolled for the present st...

I N T R O D U C T I O N Gary-Bobo and Solomon (1) have proposed that the anomalous osmotic behavior of the erythrocyte is due to a decrease of the net charge of hemoglobin which occurs when the hemoglobin concentration inside the erythrocyte is raised. Employing Donnan equilibrium studies, they subsequently (2) produced evidence to show that a hemoglobin charge dependence on hemoglobin concentr...

OBJECTIVE This study compared noninvasively measured hemoglobin and arterial hemoglobin before and after cardiopulmonary bypass in patients undergoing coronary artery or valve surgery. DESIGN Observational study with retrospective data analysis. SETTING Veterans Affairs hospital. PARTICIPANTS Thirty-five men. INTERVENTIONS None. MEASUREMENTS AND MAIN RESULTS Hemoglobin values were mea...