Two hemophilic beagles were given normal sibling. During observation 1200 A whole-body irradiation followed periods of 7 and 24 mo, there was no by a successful marrow graft from a evidence of factor VIII synthesis. ORTHOTOPIC TRANSPLANTATION of a normal liver into a hemophilic dog results in complete correction of the deficiency of factor VIII.”3 However, there are significant extrahepatic sou...

Normal human antihemophilic factor (AHF, factor VIII) and the protein antigenically related to it in hemophilic plasma both appeared in the void volume of columns of agarose (Sepharose 4B) during purification of these agents. On ultracentrifugation upon sucrose gradients, both agents had sedimentation characteristics similar to those of an S30 marker. After reduction, the polypeptide chains of ...

WEBSTER, WILLIAM P., CHARLES F. ZUKOSKI, PETER HUTCHIN, ROBERT L. REDDICK, STANLEY R. MANDEL, AND GEORGE D. PENICK. Plasma factor VIII synthesis and control as revealed by canine organ transplantation. Am. J. Physiol. 220(5) : 1147-1154. 1971.The synthesis and control of factor VIII (antihemophilic factor, AHF) have been studied by transplanting livers, spleens, and kidneys into hemophilic and ...

have indicated that normal cell-free human plasma contains some factors which are deficient in hemophilia. There is evidence that by the parenteral administration of derivatives of normal cell-free plasma in hemophilia, the coagulation defect can be modified toward normal. The present communication reviews some of the older work on this subject and presents new evidence accumulated during the p...

Hepatitis C virus (HCV) infection is often observed in hemophilic patients who received a blood transfusion of clotting factor concentrates before the mid-1980s, and this increases comorbidity and mortality rates. About 80% of HCV-infected patients have chronic HCV infections, and at least 20% develop end-stage liver disease (ESLD). In Korea, anti-HCV positivity in 1999 was reported to be 49.1%...

Hemophilia is the most common of the severe bleeding disorders and if not properly managed since early infancy can lead to chronic disease and lifelong disabilities. However, it enjoys the most efficacious and safe treatment among the most prevalent monogenic disorders. Hemophilia should be considered in the neonatal period in the case of unusual bleeding or in the case of positive family histo...

Aim: The aim of this paper is to review the pathophysiology, risk factors, prevention and treatment of osteoporosis in persons with hemophilia (PWH). Study Design and Methodology: In a search of PubMed up to September 24, 2013 using as keywords "osteoporosis" and "hemophilia" the author found 61 references, of which only the 22 focused on the aim of this study were revised. Results: Prevention ...

Hemophilia is a rare bleeding disorder that is attributed to a defi ciency of coagulation factors VIII, IX and XI. This defi ciency leads to a tendency of moderate to severe bleeding. This disorder occurs mainly in males, who represent 97.32% of cases.1 Hemophilia A is caused by a factor VIII (FVIII) defi ciency.2 Globally it is estimated that the prevalence of hemophilia A in 2012 was 363,668 ...

Bleeding times were performed on 71 hemophiliacs using the Simplate II device. Eight patients receiving Indocin or Motrin for hemophilic arthropathy were evaluated separately from the remaining 63 who had a mean bleeding time of 7.65 +/- 3.20 min (1 SD) compared to the control group of 5.35 +/- 1.49 min (p less than 0.005). No difference was found when 26 mild hemophiliacs who had received less...