As revealed by electron microscopy and electron diffraction, the physical state of ferric hydroxide micelles contained in iron-dextran, saccharated iron oxide, and hydrous ferric oxide ("ferric hydroxide") differs notably from the state of the ferric hydroxide in ferritin or hemosiderin. By virtue of this difference one can trace the intracellular transformation of colloidal iron, administered ...

A. Bourlond, Ch. Pirard, Department of Dermatology, Faculty of Medicine, Catholic University of Louvain, 52, avenue E. Mounier (Tour Vésale), B–1200 Brussels (Belgium) We were interested to read the paper of Tegelberg-Stassen et al. [1], and we adhere without restriction to their conclusions. As a matter of fact, at the Department of Dermatology, we have treated all our cases of toxic epidermal...

Superficial siderosis (SS) of the CNS is a rare and often unrecognized condition. Caused by hemosiderin deposition from chronic, repetitive hemorrhage in the subarachnoid space, it results in parenchymal damage in the subpial layers of the brain and spinal cord. T2-weighted MRI shows the characteristic hypointensity of hemosiderin deposition, classically occurring around the cerebellum, brainst...

was first described by Hartman and Chausser in i88i as " bronze diabetes " because of the association of skin pigmentation with diabetes mellitus. Von Recklinghausen in 1889 showed that the pigmentation of the skin and viscera was due to deposits of hemosiderin and hemofuscin. Hemo-chromatosis was considered quite rare, being clinically diagnosed only three times in i6o,ooo admissions to the Jo...