Cardiopulmonary bypass (CPB) is a unique clinical scenario that results in widespread activation of the hemostatic system. However, surgery also results in normal increases in coagulation activation, platelet activation, and fibrinolysis that are associated with normal wound hemostasis. Conventional CPB interferes with normal hemostasis by diluting hemostatic cells and proteins, through reinfus...

BACKGROUND As many as 80% of diabetic patients die from major thrombotic complications of atherosclerosis, stroke and myocardial infarction. Plasma and cellular components of the hemostatic system are often abnormal in diabetic patients, and some of these abnormalities may play a role in the high risk of thrombosis in these patients. MATERIALS AND METHODS Clinical studies imply that certain h...

STUDY DESIGN An in vivo study on the effects of an agent for scar prevention in a dog laminectomy model. OBJECTIVE To examine the anti-adhesion properties of a thrombin-based hemostatic gelatin (FLOSEAL; Baxter International Inc., Deerfield, IL). SUMMARY OF BACKGROUND DATA Postlaminectomy dural adhesion sometimes causes symptomatic problems. Although a new type of hemostatic agent, a thromb...

The objective of this study was to determine the response of hemostatic dressings. Coagulation and fibrinolytic systems, red blood cell parameters, platelet and leukocyte counts were evaluated after the application of hemostatic dressings: QuikClot, Chitoauze and Celox gauze. The experiment was performed on ten pigs.

Studies involving 125 patients were carried out to determine the level of activation of the markers of the hemostatic system and their contribution to the prevention and early diagnosis of complications in patients with acute destructive pancreatitis. Levels of D-dimer and fibrinopeptide A (FpA) were determined in patients. The APACHE II and SOFA scores were used to assess disease severity. Fur...

To accelerate healing of severe hemorrhagic wounds, a novel highly absorbent hemostatic dressing composed of a Tencel®/absorbent-cotton/polylactic acid nonwoven base and chitosan/nanosilver antibacterial agent was fabricated by using a nonwoven processing technique and a freeze-drying technique. This study is the first to investigate the wicking and water-absorbing properties of a nonwoven base...

PURPOSE To evaluate the hemostatic effect of intraarticular injection of a thrombin-based hemostatic agent in total knee arthroplasty (TKA). MATERIALS AND METHODS We performed a prospective randomized controlled trial on the use of a thrombin-based hemostatic agent in patients undergoing unilateral TKA. A total of 100 TKA patients were enrolled, with 50 patients randomized into the study grou...

BACKGROUND AND OBJECTIVE Previous studies on Danqi Piantan Jiaonang (DPJ, NeuroAid), a traditional Chinese medicine, in stroke patients showed promising results. Our aim was to determine the safety of DPJ in normal subjects and stroke patients through a series of studies assessing its immediate and long-term effects, alone and in combination with aspirin, on hematological, hemostatic, and bioch...

Clinical scenario: An otherwise healthy 25-year-old woman returns to your office for management of chronic primary immune thrombocytopenia. She was diagnosed 6 months earlier and continues to require prednisone 15 mg daily and periodic infusions of intravenous immunoglobulin to maintain a hemostatic platelet count. You discuss second-line treatment options, including splenectomy. The patient as...

Ovarian hyperstimulation syndrome (OHSS) is a complication that occurs in the luteal phase of an induced hormonal cycle. In most cases, the symptoms are self-limited, and spontaneous regression occurs [1]. Mild manifestations of OHSS include transient lower abdominal discomfort, nausea, vomiting, diarrhea, and abdominal distension. Life-threatening OHSS can progress to adult respiratory distres...