Renal homotransplantation was performed in 185 patients between March 1962 and April 1968. None of the recipients, who were aged 3 to 55 years, had known liver disease prior to transplantation, although in 39 of the earlier cases adequate biochemical tests were not obtained preoperatively to establish this fact. In the other 146, hepatic function was studied before operation and at frequent int...

Introduction: Burden of disease in case of renal disorders is a proverbial ice-berg where very little is manifested and a lot remains undiagnosed. The patients present to a nephrologist when it is too late. In this context epidemiological studies are important to understand and treat renal diseases. This study was undertaken over a period of ten years at a tertiary care centre at Allahabad (Ind...

The kidney plays a key role in the maintenance of normal magnesium balance. The distal tubule of the kidney, namely the thick ascending limb of the loop of Henle and the distal convoluted tubule, is crucial for the regulation of serum magnesium levels and body magnesium content. The identification of molecular defects related to rare inherited magnesium losing disorders has contributed greatly ...

BACKGROUND Increased cancer incidence, particularly lymphoproliferative disease, is a complication of immunosuppression in organ transplantation. Non-Hodgkin's lymphomas (NHLs) occur frequently during the first year after transplantation, more so in North America than in Europe. METHODS This study audited and correlated the demographic, clinical, pathological, and outcome features of post-tra...

At the early stage of chronic kidney disease (CKD), the systemic mineral metabolism and bone composition start to change. This alteration is known as chronic kidney disease-mineral bone disorder (CKD-MBD). It is well known that the bone turnover disorder is the most common complication of CKD-MBD. Besides, CKD patients usually suffer from vascular calcification (VC), which is highly associated ...

Thrombotic microangiopathy (TMA) is a pathological process involving thrombocytopenia, microangiopathic haemolytic anaemia and microvascular occlusion. TMA is common to haemolytic uraemic syndrome (HUS) associated with shiga toxin or invasive pneumococcal infection, atypical HUS (aHUS), thrombotic thrombocytopenic purpura (TTP) and other disorders including malignant hypertension. HUS complicat...

The full complement of nephrons is present at birth, although newborn nephrons are heterogeneous in glomerular size and proximal tubule length. Anatomy and function mature postnatally. Although fetal urine is excreted into the bladder by 10 to 11 weeks of gestation, the ability to conserve and excrete sodium, concentrate urine, and reabsorb substrates such as glucose evolves to maturity over th...

This cross-sectional study was performed to determine ocular findings in renal transplant recipients and to correlate them with certain clinical characteristics related to transplantation. The study was performed on 150 patients who had received a renal transplant at least three months earlier and had serum creatinine levels < 3 mg/dL. All patients underwent a complete ophthalmologic examinatio...

The genetic basis and cellular defects of a number of primary magnesium wasting diseases have been elucidated over the past decade. This review correlates the clinical pathophysiology with the primary defect and secondary changes in cellular electrolyte transport. The described disorders include (1) hypomagnesemia with secondary hypocalcemia, an earlyonset, autosomal-recessive disease segregati...

Renal failure is a frequent complication in advanced liver disease (Conn, 1973; Papper, 1978). Gastrointestinal bleeding and forced diuresis may be the causes in fulminant hepalic. failure and cirrhosis (Hecker and Sherlock, 1956; Shear et al., 1965). Hepatic coma or an associated metabolic abnormality may affect renal function or aggravate pre-existing renal abnormalities in severe liver disea...