Abstract Background Biliary atresia is associated with considerable morbidity, and it the most frequent indication for pediatric liver transplantation. Hepatic portoentostomy (HPE), Kasai procedure, used commonly as first line of treatment but its long-term efficacy still remains controversial. In this study we decided to illustrate perioperative clinical, biomarkers, histopathological, surgica...

background: cadmium (cd) intoxication can cause oxidative stress and involve the antioxi-dant defense system in hepatocytes. administration of vitamin c, chitosan, or a combination of both may prevent cd-induced oxidative damage. methods:cyprinus carpio were distributed into six groups. the control group received normal feed (group i). group ii was exposed to 0.2 mg.l-1 cadmium chloride. group ...

OBJECTIVE The pathophysiological mechanisms to explain the association between risk of type 2 diabetes and elevated concentrations of γ-glutamyltransferase (GGT) and alanineaminotransferase (ALT) remain poorly characterized. We explored the association of liver enzymes with peripheral and hepatic insulin resistance, insulin secretion, insulin clearance, and glucagon concentration. RESEARCH DE...

BACKGROUND Chronic hepatitis B (CHB) remains a major public health problem worldwide, and the prevalence of CHB patients with hepatic steatosis is gradually increasing. Noninvasive approaches for the assessment of hepatic steatosis have been developed as alternatives to liver biopsy. OBJECTIVES This study evaluated the diagnostic performance of the fat attenuation parameter (FAP) measured by ...

Graft-versus-host disease (GVHD) is a common complication of allogeneic bone marrow transplantation (BMT). Upregulation of inflammatory cytokines precedes the clinical presentation of GVHD and predicts its severity. In this report, thiol/redox metabolomics was used to identify metabolic perturbations associated with early preclinical (Day+4) and clinical (Day+10) stages of GVHD by comparing eff...

introduction: bone marrow transplantation is a good therapeutic modality for beta thalassemia. liver complications are one of the major causes of morbidity and mortality following bmt. determination of the factors of liver injury leads to earlier  diagnosis after bmt and improves prognosis. method: we studied 113 major beta thalassemic patients who have been transplanted from 1990- 2000 in bone...

background: bone marrow transplantation is a good therapeutic modality for beta thalassemia. liver complications is one of the major causes of morbidity and mortality following bmt. determination of the factors of liver injury leads to earlier diagnosis after bmt and improves prognosis. materials and methods: we studied 113 major beta thalassemic patients who have been transplanted from 1990- 2...

background: currently, non-invasive methods for screening atrophic gastritis and gastric cancer are lacking. the purpose of this study was to evaluate the value of serological parameters including serum pepsinogen i (pgi), pepsinogen ii (pgii) and pepsinogen i: ii ratio for the screening atrophic gastritis and gastric cancer.   methods : the study population consisted of 132 dyspeptic patients ...

Type 2 diabetes is a chronic metabolic disease that results from insulin resistance in the liver, muscle, and adipose tissue and relative insulin deficiency. The endoplasmic reticulum (ER) plays a crucial role in the regulation of the cellular response to insulin. Recently, ER stress has been known to reduce the insulin sensitivity of the liver and lead to type 2 diabetes. However, detailed mec...

BACKGROUND Diabetes mellitus is an alarming life style disease in the modern world. Exploitation of the anti-diabetic drugs for the amelioration of diabetes and associated life style diseases has become an imperative concern. In this milieu, this study was designed to explore the plausible effects of metformin intervention on hepatic and renal functions in a rat model of alcoholic liver disease...