نتایج جستجو برای: hepatitis b immune epitopes
تعداد نتایج: 1188089 فیلتر نتایج به سال:
Escape mutations are believed to be important contributors to immune evasion by rapidly evolving viruses such as hepatitis C virus (HCV). We show that the majority of HCV-specific cytotoxic T lymphocyte (CTL) responses directed against viral epitopes that escaped immune recognition in HCV-infected chimpanzees displayed a reduced CDR3 amino acid diversity when compared with responses in which no...
BACKGROUND Loss of antibody reactivity against linear epitopes of parvovirus B19 (B19) capsid proteins VP1 and VP2 occurs after infection; however, it is unclear whether B cell memory is established against linear epitopes. METHODS B cell enzyme-linked immunospot assay was used to evaluate B19-specific B cell memory in volunteer donors (n=22). RESULTS B cell memory is maintained against con...
VIRUSES THAT DEFY HOST IMMUNE RESPONSES AND PERSIST OR RECUR TAKE A HUGE TOLL ON GLOBAL human health. Many of these, including HIV-1, infl uenza viruses, and several fl aviviruses (such as dengue, hepatitis C, and West Nile virus) rapidly proliferate, frequently mutate, and evolve highly variable surface structures. The effectiveness of such immune escape mechanisms has thwarted multiple attemp...
INTRODUCTION The Hepatitis B Virus (HBV) genome contains four ORFs, S (surface), P (polymerase), C (core) and X. S is completely overlapped by P and as a consequence the overlapping region is subject to distinctive evolutionary constraints compared to the remainder of the genome. Specifically, a non-synonymous substitution in one coding frame may produce a synonymous substitution in the alterna...
HIV and hepatitis B virus (HBV) coinfection increases HIV and HBV replication, hepatitis flares, and risk of progression to chronic HBV infection, cirrhosis, and hepatocellular carcinoma. HIV and HBV coinfection decreases frequency of hepatitis Be antibody (anti-HBe) and hepatitis B surface antibody (anti-HBs) seroconversion, increases risk of antiretroviral therapy-related hepatotoxicity, and ...
shigella and escherichia belong to the enterobacteriaceae family which are the cause for most of the diarrheal cases in the world. shigella can cause bacterial dysenteries and shigellosis. one of the most effective proteins for pathogenesis is invasion plasmid antigen c (ipac). other bacteria like enterotoxogenic (etec), enterohemorrhagic (ehec), and e.coli can also cause diarrhea and produce i...
BACKGROUND Mononeuropathy multiplex is a rare complication during the course of chronic hepatitis B, despite various neuropathies following acute hepatitis B having been reported previously. CASE REPORT A 30-year-old man presented with sensorimotor symptoms in multiple peripheral nerves. The serological tests for hepatitis were consistent with chronic active hepatitis B. After treatment with ...
The hepatitis B prevalence rate in adults is still at a high to intermediate level in China. Our purpose was to explore the incidence rate and protective immune barrier against hepatitis B in adults in China. A sample of 317961 participants was multi-screened for hepatitis B surface antigens (HBsAg) in a large-scale cohort of the National Hepatitis B Demonstration Project. A total of 5401 perso...
Increased clinical and scientific scrutiny is being applied to hepatitis B virus (HBV), with focus on the development of new therapeutic approaches, ultimately aiming for cure. Defining the optimum natural CD8+ T cell immune responses that arise in HBV, mediated by HLA class I epitope presentation, may help to inform novel immunotherapeutic strategies. Therefore, we have set out to develop a co...
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