OBJECTIVES Hepatitis C virus in renal transplant recipients is an independent risk factor for sickness and death. It has been shown that one might limit hepatitis C virus progression in liver transplant recipients with sirolimus-based immunosuppression. The mammalian target of rapamycin is an influential molecule for the anti-hepatitis C virus action of interferon. We report our experience with...

Background: Nephrotoxicity is referred to as rapid degeneration in kidney functioning due the toxic effects of medications. The glomerulus and proximal renal tubule are fundamental portions nephron be affected by drugs leading nephrotoxicity. Prescribed medications like antibiotics (aminoglycoside, vancomycin), amphotericin B, antidepressants (amitriptyline, fluoxetine), acyclovir, angiotensin-...

CONTEXT AND OBJECTIVE Intravenous amphotericin B deoxycholate (AmB-D) infusions, usually given over 4 hours, frequently induce nephrotoxicity and undesirable infusion-related side effects such as rigors and chills. There is evidence in the literature that the use of AmB-D in the form of continuous 24-hour infusion is less toxic than the usual four-hour infusion of this drug. Our objective was t...

Objective: For 2019 and 2020, SARS-CoV-2 has been a sensational virus. Unfortunately, treatment agent specific for not developed yet. Favipiravir is one of the antiviral agents used experimentally in SARS-CoV-2. This study aimed to determine frequency side effects seen patients hospitalized our hospital received favipiravir at any stage their treatment. Methods: Our retrospective observational ...

Background. To determine the overall incidence of hepatotoxicity in children and risk factors such as age, gender, and their outcomes. Methods. Patients who were admitted to the Pediatric Infectious Disease Clinic during the period from December 2009 through August 2013 with the diagnosis of latent TB infection were included in this study. Isoniazid hepatotoxicity was classified according to th...

conclusions the current study findings indicated that echinacea purpurea extract played an important role in the protection against den toxicity in rats. results den induced hepatotoxicity and nephrotoxicity in all the treated animals by elevated serum alt, ast, alp and bun, creatinin and total and direct bilirubin levels. ast, bun and total and direct bilirubin significantly decreased in den +...

Nephrotoxicity occurs when kidney-specific detoxification and excretion do not work properly due to the damage or destruction of kidney function by exogenous or endogenous toxicants. Exposure to drugs often results in toxicity in kidney which represents the major control system maintaining homeostasis of body and thus is especially susceptible to xenobiotics. Understanding the toxic mechanisms ...