نتایج جستجو برای: hereditary diffuse gastric cancer
تعداد نتایج: 1107433 فیلتر نتایج به سال:
Let me deal with the tone and approach issues first. I found it disappointing that the paper adopts a tone that I find somewhat arrogant and condescending. This tone is adopted throughout and is best exemplified by the concluding remarks on the last page. This impression is exacerbated by the sometimes slick use of linguistic pyrotechnics, also well exemplified in the last two pages, and partic...
Mutations in the CDH1 gene, which encodes the cell adhesion molecule E-cadherin, are associated with hereditary diffuse gastric cancer in humans. Although most of the CDH1 mutations found are truncating, leading to non-functional E-cadherin, some are missense. These missense E-cadherin mutants result in full-length proteins which, when assayed in cell culture, still retain some biological activ...
OBJECTIVES Genome-wide association studies (GWAS) have demonstrated that the single nucleotide polymorphism (SNP) MAP3K1 rs889312 is a genetic susceptibility marker significantly associated with a risk of hormone-related tumors such as breast cancer. Considering steroid hormone-mediated signaling pathways have an important role in the progression of gastric cancer, we hypothesized that MAP3K1 r...
In Hereditary Diffuse Gastric Cancer syndrome, E-cadherin germline mutations of the missense type harbour significant functional consequences. In this study, we have characterised the effect of T340A, A617T, A634V and V832M E-cadherin germline missense mutations on cell morphology, motility and proliferation. Wild-type E-cadherin and A617T expressing cells have an epithelial-like morphology, wi...
From epidemiological evidence a high salt diet is a risk factor for gastric cancer, independent of Helicobacter pylori infection, and animal studies have shown that salt promotes carcinogenesis. The G-protein β 3(GNB3) C825T polymorphism has been linked with hypertension, salt sensitivity and multiple diseases. Our aim in this study was to clarify any association of the GNB3 C825T polymorphism ...
Background and study aims: Hereditary diffuse gastric cancer (HGGC), an autosomal dominant tumor-syndrome, accounts for 1 % to 3 % of gastric cancers worldwide. Presumably 30 % to 40 % of all patients fulfilling the clinical guidelines for HDGC are carriers of a pathogenic mutation in the CDH1 gene. Patients often show multiple foci of signet ring cell carcinoma at early age and are advised to ...
PURPOSE To identify germ line CDH1 mutations in hereditary diffuse gastric cancer (HDGC) families and develop guidelines for management of at risk individuals. EXPERIMENTAL DESIGN We ascertained 31 HDGC previously unreported families, including 10 isolated early-onset diffuse gastric cancer (DGC) cases. Screening for CDH1 germ line mutations was done by denaturing high-performance liquid chro...
adenocarcinoma of the stomach was the leading cause of cancer-related death worldwide through most of the 20th century. usual presentations of gastric cancer include anorexia, epigastric pain or discomfort and weakness. rarely, patients present with unusual clinical manifestations. in this article, we report two cases with uncommon presentations of gastric adenocarcinoma. the first patient was ...
Various substances in cigarette smoke including nicotine have been shown to promote/induce cancer cell proliferation. Since cotinine has a longer half life and stability in the blood, it has become the preferred biomarker for cigarette smoking exposure. Seventy-three gastric cancer patients were included in this study. The tumor tissues were stained with H and E for pathological evaluation. The...
Various substances in cigarette smoke including nicotine have been shown to promote/induce cancer cell proliferation. Since cotinine has a longer half life and stability in the blood, it has become the preferred biomarker for cigarette smoking exposure. Seventy-three gastric cancer patients were included in this study. The tumor tissues were stained with H and E for pathological evaluation. The...
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