Herpes simplex virus (HSV) infection, though most commonly seen in the oral, perioral and genital areas, can occur anywhere on the body. After primary infection, HSV then establishes latency in sensory nerve ganglia and reactivates intermittently, precipitated by various factors. These reactivations may be recurrent and appear in a dermatomal distribution, mimicking herpes zoster, often leading...

Cold sores are caused by a herpes virus, most often the herpes simplex 1 virus. Cold sores should not be confused with canker sores, which are small ulcerations in the mouth. Rather, cold sores are fluid-filled blisters that form on the gums and the outside of the mouth and lips. The blisters, which are contagious, later break, ooze, and crust over before healing. Recurrences are common and can...

Trigeminal neuritis usually is caused by an inflammatory reaction to herpes simplex virus, which often resides within the gasserian ganglion of the trigeminal nerve. Transaxonal movement of the virus between the ganglion and peripheral nerves within the oral cavity has been documented [1 , 2]. The virus can be isolated from the painful aphthous ulcers within the oral cavity and the typical cold...

Ribonuclease is a highly active inhibitor of vaccinia virus multiplication in vitro in the chorioallantoic membrane removed from embryonated chicken eggs. It is also a highly active inhibitor of pock formation by vaccinia and herpes simplex viruses on the chorioallantoic membrane in vivo. Marked inhibitory effects were obtained with 12.5 microg. of RNase. However, complete inhibition was not ob...

Herpes simplex virus (HSV) causes a wide range of pathologies in the human central nervous system (CNS) such as stroke. It was proposed that there is an association between HSV infection and stroke with different results reported by the researchers using different methods. This study aimed to investigate the frequency of HSV among stroke patient and control groups. We detected HSV in 28 stroke ...

The fate of preexisting mRNA sequences was examined after infection by herpes simplex virus. Murine erythroid cells transformed by Friend leukemia virus were used as the host. Such cells, when exposed to 2% dimethyl sulfoxide, produce large amounts of globin and globin mRNA. The protein and its mRNA are easily recognized at 4 days by electrophoresis in high percentage acrylamide gels and by hyb...

Historically, psychotic disorder has been associated with viral infection. Herpes simplex infections and Epstein-Barr virus (EBV) among other viral infections have been implicated in psychotic disorder. Of note in this case report is psychotic disorder that occurred following reactivation of herpes simplex infection in a background of mannose-binding lecithin (MBL) deficiency, childhood EBV inf...