The effect of acyclovir on DNA synthesized in cells infected with herpes simplex virus type 1 was examined. DNA that was synthesized in infected cells in the presence of acyclovir during a short pulse with [3H]thymidine remained near the top of an alkaline sucrose gradient after centrifugation. The sedimentation characteristics of labeled DNA were not changed after chasing in isotope-free mediu...

Eight cases of disseminated herpes simplex infection unassociated with infantile eczema have been found at autopsy during the period September, 1957, to April, 1958. All but two of these were grossly malnourished. Herpetic stomatitis is very much more common than is generally appreciated. Routine studies carried out in our virus laboratory have revealed that many of the more severe and atypical...

IgG viral antibodies for herpes simplex virus -1, varicella zoster virus, cytomegalovirus, measles and mumps were studied in 76 subjects with obsessive compulsive disorder and compared with a control population. There was a significantly higher titre for some of the antibodies, most specifically for herpes simplex virus type 1 and mumps. This suggests a possible role for these viral infections ...

Several findings suggest that Herpes simplex virus-1 (HSV-1) infection plays a role in the neurodegenerative processes that characterize Alzheimer's disease (AD), but the underlying mechanisms have yet to be fully elucidated. Here we show that HSV-1 productive infection in cortical neurons causes the accumulation of DNA lesions that include both single (SSBs) and double strand breaks (DSBs), wh...

Herpes are a group of similar viruses that responsible for number infecting diseases, the most important which herpes simplex, zoster and pseudopox. Resistance to traditional antiviral medications is becoming increasingly common, making treatment such infections even more difficult. For example, usage nucleoside analogues like acyclovir target DNA-polymerase virus on regular long-term basis pro...

Unlike amantadine (1-adamantanamine), tromantadine (N-1-adamantyl-N-[2-(dimethyl amino)ethoxy]acetamide hydrochloride) inhibits herpes simplex virus type 1 (KOS strain)-induced cytopathic effect and virus replication with limited toxicity to the cells. Vero and HEp-2 cells tolerated up to 2 mg of tromantadine per 2 X 10(6) cells for 24-, 48-, or 96-h incubation periods with little change in cel...

Herpes simplex virus (HSV) infection, though most commonly seen in the oral, perioral and genital areas, can occur anywhere on the body. After primary infection, HSV then establishes latency in sensory nerve ganglia and reactivates intermittently, precipitated by various factors. These reactivations may be recurrent and appear in a dermatomal distribution, mimicking herpes zoster, often leading...

Cold sores are caused by a herpes virus, most often the herpes simplex 1 virus. Cold sores should not be confused with canker sores, which are small ulcerations in the mouth. Rather, cold sores are fluid-filled blisters that form on the gums and the outside of the mouth and lips. The blisters, which are contagious, later break, ooze, and crust over before healing. Recurrences are common and can...

Trigeminal neuritis usually is caused by an inflammatory reaction to herpes simplex virus, which often resides within the gasserian ganglion of the trigeminal nerve. Transaxonal movement of the virus between the ganglion and peripheral nerves within the oral cavity has been documented [1 , 2]. The virus can be isolated from the painful aphthous ulcers within the oral cavity and the typical cold...