Acanthamoebic keratitis, a potentially devastating infection usually associated with contact lens wear, has been recognized with increasing frequency in recent years. Once the Acanthamoeba organisms gain access to the human cornea, it is not clear which constituents of the corneal milieu provide a substrate for their growth. The growth of Acanthamoeba polyphaga was investigated on cultured mono...

Eikenella corrodens is a Gram-negative facultative anaerobe which is part of the normal human oropharyngeal flora and an opportunistic pathogen of mucous membrane tissues. We report a case of secondary E. corrodens ulcerative keratitis with hypopyon in a 39-year-old male with herpes simplex keratitis. To the best of our knowledge this is the first reported case of E. corrodens as a pathogen in ...

discussion of the mode of action of ara-C does not include reference to its incorporation into RNA, a finding that may be of critical importance. Although IUdR and BUdR are indeed incorporated into cellular DNA, not only is it not true that FUdR is similarly incorporated, but also the references cited for this are incorrect (p. 86). Although Dr. Becker interprets Table X (p. 95) to show that a ...

A case of Scedosporium apiospermum keratitis was successfully treated with oral voriconazole and penetrating keratoplasty. Voriconazole levels in the aqueous humor were 53% of the levels in plasma and exceeded the MIC for the isolate by sevenfold.

In the present study a solid-phase radioimmune assay was used for the demonstration of herpes simplex virus-specific IgG and secretory IgA antibodies in the lacrimal fluid from patients with active recurrent herpes keratitis. The method was quantitative and made it possible to test specifically for the production of secretory IgA antibodies produced during an active herpes simplex virus infecti...

A case of posterior corneal abscess with extension into the anterior chamber, in the presence of an intact corneal epithelium and clear anterior corneal stroma, occurring in a young patient is described. The patient responded to treatment with systemic and topical acyclovir. The diagnosis of presumed herpes simplex keratitis was made. We report this unusual presentation of ocular herpes manifes...

Nineteen cases of keratoconjunctivitis caused by an adenovirus serologically related to types 10 and 19 are described. Seventeen of the patients presented over a period of 7 weeks and included 4 who were involved in a minor outbreak at a factory. The presentation and clinical features closely resembled those caused by adenoviruses types 8 and 19. Mild to severe follicular conjunctivitis, superf...

The sphenopalatine ganglion block has been utilized over the last century for a wide variety of maladies. This paper provides a brief history of the use of the sphenopalatine ganglion block, a review of the sphenopalatine ganglion anatomy, and the diagnoses which currently warrant its use. The traditional transnasal sphenopalatine ganglion block is described and our modification of the traditio...

Herpes simplex virus is responsible for numerous ocular diseases, the most common of which is herpetic stromal keratitis. This is a recurrent infection of the cornea that typically begins with a subclinical infection of the cornea that establishes a latent infection of sensory ganglia, most often the trigeminal ganglia. Recurring infections occur when the virus is reactivated from latency and t...

I The effect of intraocular injection of endotoxin derived from S. marcescens was investigated in herpes simplex virus-infected rabbit eye. The findings demonstrated that a 20 fig dose of endotoxin injected intravitreously or intracorneally 3 or IS hours before virus infection produced a severe uveitis, but significantly reduced herpetic keratitis and growth of virus in the cornea. Inhibition o...