نتایج جستجو برای: high density lipoprotein hdl
تعداد نتایج: 2365572 فیلتر نتایج به سال:
BACKGROUND High-density lipoprotein (HDL) enhances cholesterol efflux from the arterial wall and exhibits potent anti-inflammatory and anti-atherosclerosis (AS) properties. Whether raised HDL levels will clinically benefit patients with acute coronary syndrome (ACS) and the value at which these effects will be apparent, however, is debatable. This study examined the HDL subclass distribution pr...
BACKGROUND In addition to lowering low density lipoprotein cholesterol (LDL-C), statin therapy also raises high density lipoprotein cholesterol (HDL-C) levels. Inter-individual variation in HDL-C response to statins may be partially explained by genetic variation. METHODS AND RESULTS We performed a meta-analysis of genome-wide association studies (GWAS) to identify variants with an effect on ...
The high density lipoprotein (HDL) receptor, scavenger receptor class B, type I (SR-BI), mediates selective cholesteryl ester uptake from lipoproteins into liver and steroidogenic tissues but also cholesterol efflux from macrophages to HDL. Recently, we demonstrated the uptake of HDL particles in SR-BI overexpressing Chinese hamster ovarian cells (ldlA7-SRBI) using ultrasensitive microscopy. In...
1 Full paper 1 Internal Medicine 2 3 Running head: LIPOPROTEIN LIPID CONCENTRATIONS IN DOGS 4 5 Lipoprotein cholesterol and triglyceride concentrations associated with dog body 6 condition score; effect of recommended fasting duration on sample concentrations in 7 Japanese private clinics 8 9 Shiho USUI 1) 17 18 2 ABSTRACT 19 The objectives of this study were to survey clinics' guidance about r...
Reducing low-density lipoprotein cholesterol (LDL-C) levels does not eliminate cardiovascular risk; most patients obtain only a 25% to 35% risk reduction. When the triglyceride level is above 200 mg/dL, non–high-density lipoprotein cholesterol (non–HDL-C) is a more precise therapeutic target than LDL-C. It can serve as an excellent proxy for assessing the total number of circulating atherogenic...
Both human serum low density lipoprotein (LDL) and high density lipoprotein (HDL) can acquire [3H]glycosphingolipids from glycosphingolipid-coated hydrophobic glass beads, but the process produces variable denaturation of LDL. However, endogenous LDL glycosphingolipid can be 3H-labeled by the galactose oxidase/NaB[3H]4 technique without structural modification. We have now demonstrated that 3H-...
Plasma very low density lipoprotein (VLDL) cholesterol and triglyceride, low density lipoprotein (LDL) cholesterol and triglyceridea, high density lipoprotein (HDL) cholesterol, glucose and insulin response (sums of 1- and 2-hour postload oral glucose levels), body mass index (BMI), and blood pressure were determined in a representative sample (n = 542) of the adult Israeli Jewish population. P...
The serum amyloid A (SAA) family of proteins consists of inducible acute-phase members and a constitutive member that are minor apolipoproteins of normal high density lipoprotein (HDL). During inflammation, HDL cholesterol and apolipoprotein A-I (apoA-I) protein are decreased, and these changes are thought to be partly related to the increase in acute-phase SAA proteins that associate with the ...
OBJECTIVE To investigate the relationship between inflammatory markers and atherogenic lipoprotein subfractions. METHODS We studied 520 eligible subjects who were not receiving any lipid-lowering therapy. The inflammatory markers including white blood cell (WBC) count, high-sensitivity C-reactive protein (hs-CRP), fibrinogen, erythrocyte sedimentation rate (ESR), and D-dimer were measured. A ...
OBJECTIVE Hepatic ATP binding cassette transporter A1 (ABCA1) expression is critical for maintaining plasma high-density lipoprotein (HDL) concentrations, but its role in macrophage reverse cholesterol transport and atherosclerosis is not fully understood. We investigated atherosclerosis development and reverse cholesterol transport in hepatocyte-specific ABCA1 knockout (HSKO) mice in the low-d...
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