The promise of PARP-inhibitors(PARPis) in the management of epithelial ovarian cancer(EOC) is tempered by the fact that approximately 50% of patients with homologous recombination (HR)-proficient tumors do not respond well to these agents. Combination of PARPis with agents that inhibit HR may represent an effective strategy to enhance their activity in HR-proficient tumors. Using a bioinformati...

It has traditionally been assumed that cochlear implant users de facto perform atypically in audiovisual tasks. However, a recent study that combined an auditory task with visual distractors suggests that only those cochlear implant users that are not proficient at recognizing speech sounds might show abnormal audiovisual interactions. The present study aims at reinforcing this notion by invest...

The authors report 4 experiments exploring the language-switching performance of highly proficient bilinguals in a picture-naming task. In Experiment 1, they tested the impact of language similarity and age of 2nd language acquisition on the language-switching performance of highly proficient bilinguals. Experiments 2, 3, and 4 assessed the performance of highly proficient bilinguals in languag...

Reading, one of the most important cultural inventions of human society, critically depends on posterior brain areas of the left hemisphere in proficient adult readers. In children, this left hemispheric cortical specialization for letter strings is typically detected only after approximately 1 y of formal schooling and reading acquisition. Here, we recorded scalp electrophysiological (EEG) bra...

Immune checkpoint inhibitors (e.g., anti-PD-1 and anti-PD-L1 antibodies) have demonstrated remarkable efficacy against hypermutated cancers such as melanomas and lung carcinomas. One explanation for this effect is that hypermutated lesions harbor more tumor-specific neoantigens that stimulate recruitment of an increased number of tumor-infiltrating lymphocytes (TILs), which is counterbalanced b...

This is a detailed critique of the empirical findings, factual claims, and logic of the empirical examination of file-sharing by Felix Oberholzer-Gee and Koleman Strumpf. It is written for a general audience and provides details of calculations, data, and industry measurements that allow replication by the reader whenever possible. October 2011: There is now a new instance of Oberholzer-Gee and...

Although filling the gap in reading comprehension gained momentum with the rise of the top-down approach, Vygotsky’ concept of scaffolding and the dual code  theory provided a strong support for the use of paratext to enhance comprehension. Scaffolding is dependent on other-regulation, one type of which is object-regulation. From this vantage-point, various types of paratext can function as sou...

The main focus of this article is to develop a better understanding of the developmental trajectories of literacy and phonological skills within Dutch-speaking children. Children at high and low risk for dyslexia were followed and compared at four different moments: kindergarten and first, third and sixth grades. Three groups were then compared: (1) dyslexic readers; (2) normal readers at high ...

the purpose of this study was to examine cook’s (2003) ‘multiple competence’ by investigating backward pragmatic transfer (from l2 [english] to l1 [persian]) in refusals to invitations. it explored participants’ frequency and content of refusal strategies in l1 regarding the status (i.e., power and distance) of interlocutors and the proficiency level of efl learners. the participants were persi...