The present research was designed to evaluate different matrix, drug-in-adhesive and reservoir formulations of fentanyl transdermal patches. The target was to design drug-in-adhesive patches (DIAPs); a full factorial design was used. Different types and amounts of liquid, pressure-sensitive adhesives (PSAs) were used and evaluated with respect to drug release and adhesive properties. A very sim...

The objective of the present research was to develop a bilayer tablet of propranolol hydrochloride using superdisintegrant sodium starch glycolate for the fast release layer and water immiscible polymers such as ethylcellulose, Eudragit RLPO and Eudragit RSPO for the sustaining layer. In vitro dissolution studies were carried out in a USP 24 apparatus I. The formulations gave an initial burst e...

Present study was undertaken to assess the potential of Glycerosomes as a novel drug delivery system for topical application of Minoxidil. Pre-formulation studies were done for identification of drug as well as for determination of its physiochemical properties. Spectra of various mixtures of drug and excipients do not show any additional peak thus, indicating compatibility with each other. Gly...

This paper compares the correlation dimension (D2) and Higuchi fractal dimension (HFD) approaches in estimating BIS index based on of electroencephalogram (EEG). The single-channel EEG data was captured in both ICU and operating room and different anesthetic drugs, including propofol and isoflurane were used. For better analysis, application of adaptive segmentation on EEG signal for estimating...

The applicability of gallic acid loaded zein (Ze-GA) electrospun fibre mats towards potential active food packaging material was evaluated. The surface chemistry of the electrospun fibre mats was determined using X-ray photon spectroscopy (XPS). The electrospun fibre mats showed low water activity and whitish colour. Thermogravimetric analysis (TGA) and Attenuated Total Reflectance-Fourier Tran...

A dissolution test for fesoterodine low dose extended-release tablets using liquid chromatographic (LC) method equipped with a C18 monolithic column was developed and validated. LC system was operated isocratically at controlled temperature (40 °C) using a mobile phase of acetonitrile:methanol:0.03 M ammonium acetate (pH 3.8) (30:15:55, v/v/v), run at a flow rate of 1.5 mL/min and detected at 2...

Zidovudine-ethylcellulose microspheres were prepared by water-in-oil-in-oil double emulsion solvent diffusion method. Spherical free flowing microspheres having an entrapment efficiency of 32-54% were obtained. The effect of polymer-drug ratio, surfactant concentration for secondary emulsification process, volume of processing medium and stirring speed of secondary emulsification process was ev...

The advent of the polyrnerase chain reaction (PCR) is transforming many aspects of molecular biology. An example of this is the field of ‘molecular archaeology’ the retrieval of DNA sequences from ancient tissues which owes its very existence to this technique [ 11. The ability of the PCR to amplify a few intact DNA molecules that are extracted from old tissues has for the first time ‘made it p...

Perturbative gravity in global de Sitter space is subject to so-called linearization stability constraints: If they are to couple consistently to the gravitational field, quantum states must be invariant under the de Sitter isometries. While standard Fock spaces contain no de Sitter-invariant states apart from (possibly) the vacuum, a full Hilbert space of de Sitter-invariant quantum states can...

In an earlier study connectin, an elastic protein of striated muscle, was found to be associated with "gap filaments" originating from the thick filaments in the myofibril, but it was not clear whether it extends to Z lines or not (Maruyama, K., H. Sawada, S. Kimura, K. Ohashi, H. Higuchi, and Y. Umazume, 1984, J. Cell Biol., 99:1391-1397). In the present immunoelectron microscopic study using ...