PURPOSE Hypochlorous acid, a product of neutrophil myeloperoxidase, is a powerful enhancer of antigen processing and presentation. In this study, we examine whether ovarian epithelial cells (SK-OV-3) exposed to hypochlorous acid can stimulate T cells from patients with ovarian epithelial cancer that recognize common tumor antigens as well as autologous tumor. EXPERIMENTAL DESIGN T cells from ...

Pancreatic cancer is the eighth leading cause of cancer death worldwide. Patients with pancreatic cancer are normally diagnosed at an advanced stage and present poor survival rate. Ovatodiolide (OV), a bioactive macrocyclic diterpenoid isolated from Anisomeles indica, showed cytotoxicity effects in pancreatic cancer cells by inhibiting cell proliferation and inducing apoptosis. Moreover, not on...

In an ongoing open-label extension (OV-1004), patients with Lennox-Gastaut syndrome who had completed 1 of 2 randomized controlled trials (OV-1002 [Phase II] or OV-1012 [Phase III]) are receiving clobazam at dosages ≤2.0 mg/kg/day (≤80 mg/day). Of 306 eligible patients from OV-1002 or OV-1012, 267 entered the open-label extension. As of the interim date, July 1, 2010, 213 patients (79.8%) had r...

How the eye forms has been one of the fundamental issues in developmental biology. The retinal anlage first appears as the optic vesicle (OV) evaginating from the forebrain. Subsequently, its distal portion invaginates to form the two-walled optic cup, which develops into the outer pigmented and inner neurosensory layers of the retina. Recent work has shown that this optic-cup morphogenesis pro...

Bovine papular stomatitis virus (BPSV) and orf virus (ORFV), members of the genus Parapoxvirus of the Poxviridae, are etiologic agents of worldwide diseases affecting cattle and small ruminants, respectively. Here we report the genomic sequences and comparative analysis of BPSV strain BV-AR02 and ORFV strains OV-SA00, isolated from a goat, and OV-IA82, isolated from a sheep. Parapoxvirus (PPV) ...

Surgical resection of solid primary malignancies is a mainstay of therapy for cancer patients. Despite being the most effective treatment for these tumors, cancer surgery has been associated with impaired metastatic clearance due to immunosuppression. In preclinical surgery models and human cancer patients, we and others have demonstrated a profound suppression of both natural killer (NK) and T...

In this paper, by using the sequence of adjointable operators from pro-C*-algebra $ mathcal{A} $ into a Hilbert $ mathcal{A} $-module $ E $. We introduce frames with bounds in pro-C*-algebra $ mathcal{A} $. New frames in Hilbert modules over pro-C*-algebras are called standard $ ast $-frames of multipliers. Meanwhile, we study several useful properties of standard $ ast $-frames in Hilbert modu...

Controlled frames in Hilbert spaces have been recently introduced by P. Balazs and etc. for improving the numerical efficiency of interactive algorithms for inverting the frame operator. In this paper we develop a theory based on g-fusion frames on Hilbert spaces, which provides exactly the frameworks not only to model new frames on Hilbert spaces but also for deriving robust operators. In part...

We report F U SE far-UV spectroscopy of the prototypical dwarf starburst galaxy NGC 1705. These data allow us for the first time to directly probe the coronal-phase (T = few ×10 5 K) gas that may dominate the radiative cooling of the supernova-heated ISM and thereby determine the dynamical evolution of the starburst-driven outflows in dwarf galaxies. We detect a broad (∼100 km s −1 FWHM) and bl...

In this study we investigated the generality of the electrophysiological mechanisms underlying verb agreement relations by looking not only at subject-verb (SV) but, moreover, at object-verb (OV) agreement phenomena in Basque-a language in which both the subject and the object have to agree with the verb. We first provide event-related potentials (ERP) evidence for processing differences in SV ...