introduction: stroke is the third important reason of death in adults and an important cause of adult disability. previous studies suggest that tgf-alpha can induce neurogenesis after stroke. here in, we studied neurogenesis effects of the tgf-alpha on subventricular zone following ischemia-reperfusion. male wistar rats (250-300 g) were divided into ischemia and treatment groups. after inductio...

Methamphetamine (METH) abuse causes neurodegeneration. Medicinal herb such as crocin has neuroprotective properties. The current study evaluates the role of CREB-BDNF signaling pathway in mediating the neuroprotective effects of crocin against METH-induced neurodegeneration in rats. Sixty adult male rats were divided randomly into group 1 and group 2 which received 0.7 mL/rat ...

Neonatal isolation (NI) has detrimental consequences on the hippocampal neurons of rat neonates. It been reported to enhance neuronal cell death and impair memory behaviors. We conducted this study assess effects NI apoptosis recognition impairment in hippocampus One group male Wistar neonates exposed NI; reared with 1-hour neonatal for eight consecutive days (P2-P9). On other hand, control nor...

Alzheimer’s disease is a chronic neurodegenerative among the elderly population. Various genetic, environmental and lifestyle factors have been associated with etiology of disease. Cigarette smoke has reported to be major predisposing factor for contributes development. Conversely, studies beneficial effects brain training on condition. The purpose this study was evaluate effect task in cigaret...

Alzheimer’s disease (AD) is a major public health priority. Hippocampus one of the most affected areas brain and easily accessible as biomarker using MRI images in machine learning for diagnosing AD. In learning, entire image slices showed lower accuracy AD classification. We present select method by landmarks on hippocampus region images. This study aims to see which views have higher Then, ge...

Measurements of blood flow in the human hippocampus are complicated by its relatively small size, unusual anatomy and patterns of blood supply. Only a handful of arterial spin labeling (ASL) MRI articles have reported regional cerebral blood flow (rCBF) values for the human hippocampus. Numerous reports have found heterogeneity in a number of other physiological and biochemical parameters along...

The role of the hippocampus in memory is commonly investigated by comparing fear conditioning paradigms that differ in their reliance on the hippocampus. For example, the dorsal (septal) portion of the hippocampus is involved in trace, but not delay fear conditioning, two Pavlovian paradigms in which only the relative timing of stimulus presentation is varied. However, a growing literature impl...