UNLABELLED Cervical metastasis represent the most relevant prognostic factor in carcinomas of the mouth. Clinical and histological factors are associated with the development of cervical metastasis; however, research on molecular factors has been broadly carried out in recent years. AIM The aim of this study is to analyze the association of the Cyclin D1 as a risk factor for the presence of c...

OBJECTIVE To examine the relation between the serum levels of tumour necrosis factor alpha (TNFalpha), soluble tumour necrosis factor receptors (sTNF-R), and the histological pattern of rheumatoid synovitis. METHODS An enzyme linked immunosorbent assay (ELISA) was used to measure TNFalpha, p55 sTNF-R, and p75 sTNF-R concentrations in the serum of 43 patients with rheumatoid arthritis (RA) and...

BACKGROUND TP53 mutations are among the most common mutations found in lung cancers, identified as an independent prognostic factor in many types of cancers. The purpose of this study was to investigate the frequency and prognostic impact of TP53 mutations in never-smokers and in different histological subtypes of lung cancer. METHODS We analyzed tumor tissue from 394 non-small cell carcinoma...

Background. Gastric cancer is one of the leading causes cancer-related deaths across world and in Middle East. Human epidermal growth factor receptor 2 (HER2) overexpression has been observed gastric cancers. Trastuzumab, a recombinant monoclonal antibody targeting HER2 protein, being used for treatment metastatic cancer. Objective. To study frequency association with age, gender, histopatholog...

Abstract Background Mesenchymal stem cells (MSCs) provide potential treatments for peritoneal fibrosis. However, MSCs cultured in media containing serum bring risks of infection and other problems. In this study, we compared the effect human serum-free medium (SF-MSCs) on fibrosis with that 10% fetal bovine (10%MSCs). Methods Peritoneal was induced by intraperitoneally injecting 0.1% chlorhexid...

HYPOTHESIS Histological grade of hepatocellular carcinoma (HCC) is an important prognostic factor affecting patient survival after orthotopic liver transplantation (OLT). DESIGN Retrospective analysis. SETTING University-based teaching hospital. PATIENTS Of 952 OLTs performed between June 1991 and January 1999, 56 OLT recipients had histologically proven HCC in the explant liver. Of those...

We report a rare case of synchronous malignant peritoneal mesothelioma the biphasic histological type and neuroendocrine tumor (NET) rectum without history asbestos exposure.
 During 2 years since manifestation disease patient underwent 3 cytoreductive surgeries (CRS): removal sigmoid mesentery, resection rectosigmoid junction completeness cytoreduction (CC) 0 (2017), omentectomy partial p...

Background: Basic fibroblast growth factor (bFGF) is a glycoprotein with stimulating ability of angiogenesis. In addition, bFGF plays an important role in wound healing process in some tissues for example gastrointestinal tract, but its ability for discrimination of various stages of wound severity in these diseases was not reported. Therefore, we aimed to determine the bFGF levels in gastric u...

UNLABELLED Diagnosis of Sjögren's syndrome (SS) is complex and the usefulness of labial minor salivary glands biopsy in this process remains controversial. OBJECTIVE to evaluate the clinical and laboratorial profile and histological features on labial minor salivary glands from patients under investigation of SS. STUDY DESIGN clinical charts from 38 patients under suspicion of SS and submit...