To address the reliability challenges due to failures and planned outages, Internet Service Providers (ISPs) typically use two backbone routers at each central office with access routers connecting to them in a dual-homed configuration. At the IP layer, providers deploy redundant backbone routers and redundant transport equipment interconnecting these routers, with the goal of providing reliabi...

BACKGROUND Previous studies have demonstrated that macrophages and CD4+ T lymphocytes play pivotal roles in collateral development. Indirect evidence suggests that CD8+ T cells also play a role. Thus, after acute cerebral ischemia, CD8+ T cells infiltrate the perivascular space and secrete interleukin-16 (IL-16), a potent chemoattractant for monocytes and CD4+ T cells. We tested whether CD8+ T ...

With the development of audio encoding standards and IP technology, voice over IP (VoIP) is becoming quite popular. However, high-quality voice data over current networks without QoS Support, such as Internet and UMTS, still posses several challenging problems because of the adverse effects caused by network bandwidth restrictions and complex dynamics. One approach to provide QoS for VoIP appli...

Most juvenile chronic myelogenous leukemia (JCML) cells have limited long-term proliferative capacity, and only a minority of immature cells give rise to colonies in semisolid cultures. Clonogenic JCML progenitors cannot be maintained in culture because they differentiate, and within a few weeks the leukemic clone is lost. This makes it difficult to identify the cell that initiates and maintain...

PlanetLab is a global scale platform for experimentation of new networking applications in a real environment. It consists of several nodes, offered by academic institutions or companies spread all over the world, that can be shared by the networking community for its tests. The main drawback of PlanetLab is its scarce heterogeneity in terms of the access technologies it offers. In this paper w...

Multihoming, the practice of connecting to multiple providers, is becoming highly popular. Due to the growth of the BGP routing tables in the Internet, the way to multihome in IPv6 is required to preserve the scalability of the interdomain routing system. A proposed method is to assign multiple provider-dependent aggregatable (PA) IPv6 prefixes to each site, instead of a single provider-indepen...

Abstract The highly immunosuppressive tumor microenvironment (TME) stimulates cancer cells resistance to immunotherapy. We have previously shown that a live-attenuated Brucella melitensisΔ vjbR(BmΔ vjbR) bacterial strain, breaks cell immunotherapy by remodeling the TME and facilitating infiltration of cytotoxic CD8 +T (CTLs) into tumor. As result, there was shrinkage size significant improvemen...

BACKGROUND Recent literature suggests that blood pressure variability (BPV) predicts outcome beyond blood pressure level (BPL) and that antihypertensive drug classes differentially influence BPV. We compared calcium channel blockers, angiotensin-converting enzyme inhibitors, and angiotensin receptor blockade for effects on changes in self-measured home BPL and BPV and for their prognostic signi...