To investigate the regulation of the human fatty acid synthase gene by the thyroid hormone triiodothyronine, various constructs of the human fatty acid synthase promoter and the luciferase reporter gene were transfected in combination with plasmids expressing the thyroid hormone and the retinoid X receptors in HepG2 cells. The reporter gene was activated 25-fold by the thyroid hormone in the pr...

Acute parathyroid hormone exposure induces vascular smooth muscle relaxation. In contrast, continuous infusion of parathyroid hormone leads to vasoconstriction and an elevation of blood pressure. Despite the known effects of parathyroid hormone on vascular smooth muscle, possible direct effects on the vascular endothelium have not previously been investigated. Using a human umbilical vein endot...

The androgen receptor (AR) is expressed in many cell types, and its related signaling widely investigated hormone-dependent cancers such as prostate breast. significance of the AR, however, has been detected even other cancers, including gastric, bladder, kidney, lung, hepatic, pancreatic, which growth spreading are not strictly or notoriously dependent on sex steroid hormone action. incidence ...

This review touches on new insights into the possible role of Vitamin D receptors genetic polymorphisms, and steroid in patients diagnosed with breast cancer. is most common cancer women; further, it creates diverse illnesses among diseased patients, prognosis linked different subtypes present hormone receptors. Most studies focus epidemiology disease. However, fewer are done genes polymorphism...

In 2019, the coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome corona virus 2 (SARS-CoV-2), has killed more than 6.6 millions of people around world as end 2022. The long-term impact COVID-19 is persisted, including its on male reproduction. SARS-CoV-2 enters into host cells using angiotensin-converting enzyme (ACE2) and transmembrane serine protease (TMP...

Major salivary gland tumours were studied for the presence of hormone receptors for oestrogen and progesterone. Of the eight salivary gland tumours exhibiting varied histology, none showed high affinity receptors for oestrogen or progesterone. Salivary tissue from four patients with non-neoplastic salivary gland disease was also studied and found not to contain high affinity receptor sites. The...

Receptor disorders may produce specific clinical manifestations resembling hypo-or hyper-function of related endocrine gland. Receptor disorders can be divided into five categories: 1)Altered receptor concentration exists in insulin resistance seen in obsity, familial hypercholes­terolemia and in testicular feminization. 2) Altered receptor affinity can be seen in fasted obese patients, acromeg...

17α-estradiol (αE2), an endogenous stereoisomer of the hormone 17β-estradiol (E2), is capable binding to estrogen receptors (ER). We aimed mathematically describe, using experimental data, possible interactions between αE2 and sperm ER during process capacitation develop a kinetic model. The goal was compare suggested model with previously published results E2 17α-ethynylestradiol (EE2). HPLC-M...