Simulations of electron transport are carried out by solving the Fokker-Planck equation in the diffusive approximation. The system of a single laser hot spot, with open boundary conditions, is systematically studied by performing a scan over a wide range of the two relevant parameters: (1) Ratio of the stopping length over the width of the hot spot. (2) Relative importance of the heating throug...

Multistage Interconnection Networks based on shared buuering are known to have better performance and buuer utilization than input or output buuered switches. Shared buuer switches do not suuer from head of line blocking which is a common problem in simple input buuering. Shared buuer switches have previously been studied under uniform and unbalanced traac patterns. However, due to the complexi...

Cdc25 phosphatases are key activators of the eukaryotic cell cycle and compelling anticancer targets because their overexpression has been associated with numerous cancers. However, drug discovery targeting these phosphatases has been hampered by the lack of structural information about how Cdc25s interact with their native protein substrates, the cyclin-dependent kinases. Herein, we predict a ...

multistage interconnection network. Various traffic control schemes have been proposed to handle hot-spot traffic [4–7, 17, 19, 24]. Among these schemes, the combining network [5, 6, 17], which can combine requests within a switching element accessing the same memory location, is an effective scheme for handling hot-spot traffic. It not only reduces network traffic, but also provides a fast syn...

One-third of protein formulations are multi-dose. These require antimicrobial preservatives (APs); however, some APs have been shown to cause protein aggregation. Our previous work on a model protein cytochrome c indicated that partial protein unfolding, rather than complete unfolding, triggers aggregation. Here, we examined the relative strength of five commonly used APs on such unfolding and ...

[1] Although most Central American magmas have a typical arc geochemical signature, magmas in southern Central America (central Costa Rica and Panama) have isotopic and trace element compositions with an ocean island basalt (OIB) affinity, similar to the Galapagos-OIB lavas (e.g., Ba/La < 40, La/Yb > 10, Pb/Pb > 18.8). Our new data for Costa Rica suggest that this signature, unusual for a conve...

UNLABELLED Computational solvent fragment mapping is typically performed on a single structure of a protein to identify and characterize binding sites. However, the simultaneous analysis of several mutant structures or frames of a molecular dynamics simulation may provide more realistic detail about the behavior of the sites. Here we present a plug-in for Visual Molecular Dynamics that streamli...

Scalable multiprocessors that support a shared-memory image to application programmers are typically based on physical memory modules that are distributed. Consequently, the access times for a particular processor to various parts of physical memory di er. In this paper, we explore the implications of this non-uniformity in memory access times. In particular, we study the e ect of hot-spots in ...

This paper examines crime hot spots near licensed premises in the night-time economy (NTE) to investigate whether hot spots of four different classification of crime and disorder co-occur in time and place, namely violence, disorder, drugs and criminal damage. It introduces the concept of multi-classification crime (MCC) hot spots; the presence of hot spots of more than one crime classification...