BACKGROUND The key to interpreting the contribution of a disease-associated mutation in the development and progression of cancer is an understanding of the consequences of that mutation both on the function of the affected protein and on the pathways in which that protein is involved. Protein domains encapsulate function and position-specific domain based analysis of mutations have been shown ...

Polygons can serve an important role in the analysis of georeferenced data as they provide a natural representation for particular types of spatial objects and in that they can be used as models for spatial clusters. This paper claims that polygon analysis is particularly useful for mining related, spatial datasets. A novel methodology for clustering polygons that have been extracted from diffe...

Spatial distribution rules and risk factors for syphilis were studied in Jiangsu province, People's Republic of China during 2005 and 2009. Trend surface analysis, spatial autocorrelation analysis and spatio-temporal clustering were applied with the incidence rates of the various counties in the province to determine spatial distribution rules and risk factors. Syphilis was found to be most sev...

Protecting hotspots of marine species richness may not be an effective strategy to conserve biodiversity because these sites do not coincide with hotspots of functional and phylogenetic diversity.

Recombination hotspots have previously been discovered in bacteriophage T4 by two different approaches, marker rescue recombination from heavily damaged phage genomes and recombination during co-infection by two undamaged phage genomes. The phage replication origin ori(34) is located in a region that has a hotspot in both assays. To determine the relationship between the origin and the two kind...

BACKGROUND Road traffic injuries (RTI) are a major public health epidemic killing thousands of people daily. Low and middle-income countries, such as Brazil, have the highest annual rates of road traffic fatalities. In order to improve road safety, this study mapped road traffic fatalities on a Brazilian highway to determine the main environmental factors affecting road traffic fatalities. ME...

Recombination is the main cause of genetic diversity. Thus, errors in this process can lead to chromosomal abnormalities. Recombination events are confined to narrow chromosome regions called hotspots in which characteristic DNA motifs are found. Genomic analyses have shown that both recombination hotspots and DNA motifs are distributed unevenly along human chromosomes and are much more frequen...

Article history: Received 13 October 2005 Received in revised form 17 April 2006 Accepted 26 May 2006 Available online 17 August 2006 In an effort to prioritize conservation efforts, scientists have developed the concept of biodiversity hotspots. Since most hotspots occur in countries where poverty is widespread, the success of conservation efforts depends upon the recognition that poverty can ...

Meiotic recombination generates new genetic variation and assures the proper segregation of chromosomes in gametes. PRDM9, a zinc finger protein with histone methyltransferase activity, initiates meiotic recombination by binding DNA at recombination hotspots and directing the position of DNA double-strand breaks (DSB). The DSB repair mechanism suggests that hotspots should eventually self-destr...