نتایج جستجو برای: hr roles
تعداد نتایج: 251621 فیلتر نتایج به سال:
Glycolytic enzymes are known to play pivotal roles in cancer cell survival, yet their molecular mechanisms remain poorly understood. Phosphoglycerate mutase 1 (PGAM1) is an important glycolytic enzyme that coordinates glycolysis, pentose phosphate pathway, and serine biosynthesis in cancer cells. Herein, we report that PGAM1 is required for homologous recombination (HR) repair of DNA double-str...
DNA double-strand breaks (DSBs) are one of the most detrimental lesions, as their incorrect or incomplete repair can lead to genomic instability, a hallmark of cancer. Cells have evolved two major competing DSB repair mechanisms: Homologous recombination (HR) and non-homologous end joining (NHEJ). HR is initiated by DNA-end resection, an evolutionarily conserved process that generates stretches...
Homologous recombination (HR) is the process whereby two DNA molecules that share high sequence similarity are able to recombine to generate hybrid DNA molecules. Throughout evolution, the ability of HR to identify highly similar DNA sequences has been adopted for numerous biological phenomena including DNA repair, meiosis, telomere maintenance, ribosomal DNA amplification and immunological div...
مقدمه و اهداف این مطالعه جهت تعیین اعتبار دستگاه های ارب اسکن ii و پنتاکمhr با تست استاندارد پاکی متری التراسونیک در افراد دوربین بعد از عمل جراحی لازک انجام گرفت. مواد و روش ها این مطالعه بروش توصیفی- تحلیلی انجام گردید.جامعه مورد بررسی ،بیماران مراجعه کننده به بخش لیزیک بیمارستان فارابی بودند.جمع آوری نمونه ها از شهریور ماه سال 90 آغاز شد و بمدت 9 ماه بطول انجامید. در این مطالعه 28 چشم مبت...
BACKGROUND Conflicting evidence exists regarding the effects of platelet/lymphocyte ratio (PLR) and lymphocyte/monocyte ratio(LMR) on the prognosis of colorectal cancer (CRC) patients. This study aimed to evaluate the roles of the PLR and LMR in predicting the prognosis of CRC patients via meta-analysis. METHODS Eligible studies were retrieved from the PubMed, Embase,andChina National Knowled...
Forkhead box (FOX) transcription factor family plays an important role in cancer growth and metastasis. This study aimed to determine the predictive ability of FOX genes in gastric carcinoma. A total of 360 patients with gastric from The Cancer Genome Atlas (TCGA) cohorts were collected in this study. The expression profile of FOX family were obtained from the TCGA RNAseq database. Clinicopatho...
BACKGROUND Circulating miRNAs have momentous clinical relevance as prognostic biomarkers and in the progression of solid tumors. Recognizing novel candidates of neuroblastoma-specific circulating miRNAs would allow us to identify potential prognostic biomarkers that could predict the switch from favorable to high-risk metastatic neuroblastoma (HR-NB). RESULTS Utilizing mouse models of favorab...
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