Lifelong blood cell production is dependent on rare hematopoietic stem cells (HSCs) to perpetually replenish mature cells via a series of lineage-restricted intermediates. Investigating the molecular state of HSCs is contingent on the ability to purify HSCs away from transiently engrafting cells. We demonstrated that human HSCs remain infrequent, using current purification strategies based on T...

Abstract Background Liver fibrosis (LF) is a common pathological process characterized by the activation of hepatic stellate cells (HSCs) and accumulation extracellular matrix. Severe LF causes cirrhosis even liver failure, major cause morbidity mortality worldwide. Transplantation human placental mesenchymal stem (hPMSCs) has been considered as an alternative therapy. However, underlying mecha...

Abstract Recently, Salidroside (Sal) has been demonstrated to suppress hepatic stellate cell (HSC) activation, a crucial event for liver fibrosis. Moreover, Sal reported decrease hepatocyte injury. A growing number of reports have indicated that the crosstalk between hepatocytes and HSCs is very fibrosis development. Whether Sal-treated could inhibit HSC activation unclear. Exosomes, as vital v...

Abstract Purpose of Review Hematopoietic stem cells (HSCs) maintain blood and immune cell homeostasis by balancing quiescence, self-renewal, differentiation. HSCs can be used in lifesaving transplantation treatments to create a healthy hematopoietic system patients suffering from malignant or inherited diseases. However, lack matching bone marrow donors, the low quantity single cord graft, are ...

Chiba H, Ataka K, Iba K, Nagaishi K, Yamashita T, Fujimiya M. Diabetes impairs the interactions between long-term hematopoietic stem cells and osteopontin-positive cells in the endosteal niche of mouse bone marrow. Am J Physiol Cell Physiol 305: C693–C703, 2013. First published July 24, 2013; doi:10.1152/ajpcell.00400.2012.—Hematopoietic stem cells (HSCs) are maintained, and their division/prol...

In chronic liver diseases, regardless of their etiology, the development of fibrosis is the first step toward the progression to cirrhosis, portal hypertension, and hepatocellular carcinoma. Hepatic stellate cells (HSCs) are the main profibrogenic cells that promote the pathogenesis of liver fibrosis, and so it is important to identify the molecules that regulate HSCs activation and liver fibro...

Hepatic stellate cells (HSC) changed their morphology and function including production of matrix metalloproteinases (MMPs) in response to extracellular matrix (ECM) component used as a substratum in culture. We examined in this study the regulatory role of ECM component on expression of MMPs and tissue inhibitor of metalloproteinase (TIMP) in rat HSCs cultured on polystyrene, type I collagen-c...