We have investigated the regulation mechanism of chemical stress-induced hsp70 gene expression in murine L929 cells. Our data show that chemical treatments including sodium arsenite, cadmium chloride and sodium salicylate, induced significant synthesis of hsp70 and its mRNA. The induced hsp70 gene expression appears to be regulated at the transcriptional level. A factor (CHBF), which constituti...

A large number of viruses can result in encephalitis. However, certain viruses are more prevalent in certain geographical regions. For example, Japanese encephalitis (JE) and dengue in South East Asia and West Nile in Middle East whereas Herpes simplex encephalitis (HSE) occurs all over the world without any seasonal or regional variation. Encephalitis can result in acute symptomatic seizures a...

The HSE asked the National Centre for Pharmacoeconomics (NCPE) to carry out an assessment of the applicant’s (Boehringer Ingelheim Ltd) economic dossier on the cost-effectiveness of nintedanib (Ofev®). The NCPE uses a decision framework to systematically assess whether a technology is costeffective. This includes clinical effectiveness and health related quality of life benefits, which the new ...

fault tree analysis (fta) as a probabilistic risk assessment (pra) method is used to identify basic causes leading to an undesired event, to represent logical relation of these basic causes in leading to the event, and finally to calculate the probability of occurrence of this event. to conduct a quantitative fta, one needs a fault tree along with failure data of the basic events (bes). someti...

background: today, with the development of technology, the presence and role of human resources has been highlighted in industrial environments. hence, the importance of safety culture is growing. mining is the one of the most dangerous occupations. therefore, this study was performed to determine the effect of health, safety, and environment management system (hse-ms) on safety climate in one ...

Abstract In this article, we identify ways in which the Covid-19 pandemic has exposed flaws UK’s regulatory regime for health and safety at work. The characteristics of presented particular challenges risk-based approach to regulation embraced by Health Safety Executive (HSE). We offer a critique suggest four principal areas reform. First, it is clear that HSE other enforcement bodies need an i...

fractionation studies on the sediment samples provide valuable information on the nature of the metals bound to the sediments. thirty three sediment samples of river adyar were collected during two seasons and speciation study was carried out. the industrial and domestic effluents are directed into the river course at many points in the middle and lower of the adyar river. to ascertain the exte...

conclusions overall, the results derived from these studies indicated that hospital safety levels in most of the surveyed hospitals were moderate. although the situation in hospitals is not critical, there is a need to plan and take appropriate measures to improve the safety level of the hospitals. results hospital preparedness in disaster was evaluated in three dimensions: structural, non-stru...

the safety of hydrogen generation facilities is the main concern in their process operation. this study was conducted to identify the hazards and evaluate the risks of a hydrogen generation plant. for this purpose, prha (process hazard analysis) was applied for hazard identification while lopa (layer of protection analysis) was used for risk assessment. the study was conducted in the hydrogen p...