The aim of this quality controlling study was to determine the accuracy of liquid-based cytology (LBC) with the Turbitec cytocentrifuge technique. Cervical smears of 632 women, who were referred to our CIN outpatient department, after at least two smears with ASCUS or higher were evaluated and compared with the histological outcome. In 592 cases the smears revealed abnormalities of squamous epi...

Introduction/Background Cervical cancer (CC) is one of the most common types and fourth leading cause cancer-related deaths in women. carcinogenesis multistep process cervical dysplasia development progression. Correct diagnostic effective therapy presents an important approach to reduce CC morbidity mortality. MicroRNAs epithelium cells are considered as promising markers dysplasia. M...

In this issue of the Journal, de Cremoux et al1 report a study examining the efficiency of human papillomavirus (HPV) testing using the Hybrid Capture 2 (HC2) in cervical cancer screening. In conducting this study, they focused on several factors that are emerging as important determinants of accuracy in the use of HC2 in any setting, including the following: (1) sensitivity, (2) positive predi...

Human papillomavirus (HPV) has more than 100 different types, some of which are associated with cancer. The most common example is that cervical cancer, HPV16 and HPV18. Here, we performed next-generation sequencing (NGS) to type 2436 samples obtained from Korean women elucidate the correlation between multiple infections, virus cytology. NGS revealed types 58, 56, 16 were in high-risk (HR) whe...

Background . Current issues in the cytological assessment of cervical epithelium can hamper differential diagnosis high-grade squamous intraepithelial lesion (HSIL) and cancer. Aim To determine informativity locally estimated values odd-numbered higher fatty acids as markers HSIL Materials methods. Previous original data on content biopsy primary pre-treatment cancer patients were analysed retr...

Introduction/Background The pathological changes at different severity stages of cervical intraepithelial neoplasia (CIN) can give rise to the differences in electrical properties tissues, which lay foundation for screening CIN using non-invasive and cost-effective technique bioimpedance as well paves way easy availability screening, especially developing countries thereby reduction oc...

To estimate the risk of human papillomavirus (HPV) infection for cervical malignancies, we conducted a case-control study in Japan. Abnormal cervical cell (366) and normal cell samples (1562) were tested for the presence of HPV DNA using a new PCR-based test (LCR-E7 PCR). When single HPV infections were considered, 26 different HPV types were identified in normal cervices and in low-grade squam...

Pap test involves searching of morphological changes in cervical squamous epithelial cells by pathologists or cytotechnologists to identify potential cancerous cells in the cervix. Nuclear membrane irregularity is one of the morphological changes of malignancy. This paper proposes two novel techniques for the evaluation of nuclear membrane irregularity. The first technique, namely, penalty-driv...