Serotonin (5-hydroxytryptamine, 5-HT) can stimulate the lower esophageal sphincter (LES) by indirect actions on the modulation of reflexes and by a direct action on smooth muscles. Aim:of this study was to investigate the role of 5-HT and selective 5-HT receptor subtypes in the regulation of the lower esophageal sphincter (LES) in the rat by measuring electromotor activity of the LES. Methods:T...

Elevating serotonin (5-HT) levels with selective serotonin reuptake inhibitors (SSRIs) is the most widely used treatment for depression. However, current therapies are ineffective, have delayed benefit, or cause side effects in many patients. Here, we define a mechanism downstream of 5-HT1A receptors that mediates antidepressant-like behavior and is profoundly and selectively enhanced by geneti...

An affinity-chromatography column was used to isolate and purify 5-hydroxytryptamine (serotonin, 5-HT) receptors from bovine brain frontal cortex. The affinity ligand lysergic acid ethylamidoethylbromide was synthesized and coupled to an agarose matrix via a thioether bond. Receptors in the crude cortical membrane fragments were solubilized using 3-[(3-cholamidopropyl)-dimethylammonio]-1-propan...

Introduction Aripiprazole is the third generation Antipsychotic, and Dopamine serotonin system stabiliser.It partial agonist at D2 5 HT1 A antagonist HT2.Most commonly seen adverse effects are Akathesia, fatugue,insomnia headache major advanatage less propensity for extrapyramidal side lmetabolic eefects. Objectives To report a case of Schizophrenia treated with 15mg/day developiing occular gyr...

BACKGROUND During the interdigestive state in humans, erythromycin 40 mg induces a premature activity front that starts in the stomach, while erythromycin 200 mg induces a prolonged period of enhanced antral contractile activity. AIMS To study the involvement of a cholinergic pathway in the motor effects of erythromycin using the muscarinic antagonist atropine and the neural 5-HT1 receptor ag...

Serotonin is probably unique among the monoamines in that its effects are subserved by as many as 13 distinct heptahelical, G protein-coupled receptors (GPCRs) and a ligand-gated ion channel family (5-HT3). These receptors are divided into seven distinct classes (5-HT1 to 5-HT7) largely on the basis of their structural, transductional and operational characteristics. While this degree of physic...

This study investigated the effects of bilateral injections of a serotonin (5-HT) receptor agonist into the lateral parabrachial nucleus (LPBN) on the intake of NaCl and water induced by 24-h water deprivation or by sodium depletion followed by 24 h of sodium deprivation (injection of the diuretic furosemide plus 24 h of sodium-deficient diet). Rats had stainless steel cannulas implanted bilate...

Mirtazapine is a new antidepressant that can increase noradrenergic and serotonergic neurotransmission. It is also a postsynaptic antagonist of 5-HT2 and 5-HT3. In addition, it has only a weak affinity for 5-HT1 receptors and has very weak muscarinic anticholinergic and histamine (H1) antagonist properties. We report a case of hypertensive urgency that ensued after a patient took a single low d...

1 Polysynaptic excitatory postsynaptic potentials that trigger spasms 2 after spinal cord injury in rats are inhibited by 5-HT1B and 5-HT1F receptors. 3 4 Katherine C. Murray, Marilee J. Stephens, Michelle Rank, Jessica D’Amico, 5 Monica A. Gorassini and David J. Bennett 6 Centre for Neuroscience, University of Alberta, Edmonton, Alberta, Canada 7 8 9 Running Title: 5-HT1 receptors inhibit spas...