Hydroxyurea (HU) is a well tolerated ribonucleotide reductase inhibitor effective in HIV, sickle cell disease, and blood cancer therapy. Despite a positive initial response, however, most treated cancers eventually progress due to development of HU resistance. Although RNR properties influence HU resistance in cell lines, the mechanisms underlying cancer HU resistance in vivo remain unclear. To...

normal 0 false false false en-us x-none ar-sa aim: ct number (hu) and linear attenuation coefficient contain useful information which  can be determined during usual ct scanning for the prediction of breast cancerous cells existence based on hemoglobin concentration. methods: this study used breast phantom containing major and minor vessels with diameters of 10 and 5 mm, respectively. the major...

23 24 Some unidentified RNA molecules, together with the nucleoid protein HU, were 25 suggested to be involved in the nucleoid structure of Escherichia coli. HU is a conserved 26 protein known for its role in binding to DNA and maintaining negative supercoils in the 27 latter. HU also binds to a few RNAs but the full spectrum of its binding targets in the cell 28 is not known. To understand any...

Some unidentified RNA molecules, together with the nucleoid protein HU, were suggested to be involved in the nucleoid structure of Escherichia coli. HU is a conserved protein known for its role in binding to DNA and maintaining negative supercoils in the latter. HU also binds to a few RNAs, but the full spectrum of its binding targets in the cell is not known. To understand any interaction of H...

The nucleoid-associated protein HU is one of the most abundant proteins in Escherichia coli and has been suggested to play an important role in bacterial nucleoid organization and regulation. Although the regulatory aspects of HU have been firmly established, much less is understood about the role of HU in shaping the bacterial nucleoid. In both functions (local) modulation of DNA architecture ...

Introduction: Pixel value in computed tomography (CT) gives the average linear attenuation coefficient of the scanned material in the path of the x-ray beam, being normalized to that of water. It is known that attenuation coefficient or HU value is a function of the chemical characteristic of the material and of the x-ray energy. The CT image shows the HU value by a shade of gr...

BACKGROUND Patients with neuroendocrine-related tumors and paraneoplastic encephalomyelitis (PEM) or paraneoplastic sensory neuronopathy (PSN) develop high titers of antibodies, called anti-Hu, against neuronal proteins expressed in their tumors, usually small cell lung cancer (SCLC). These tumors appear to be more indolent than those not associated with anti-Hu antibodies. The aims of this stu...