A readily available source of pure hyaluronic acid is a necessity in studies involving the ground substance of connective tissue and its relation to diverse spreading factors thought to be important in the pathogenesis of many bacterial diseases. Any objection that contamination with other mucopolysaccharides or protein of hyaluronic acid prepared from mammalian sources is generally likely, unl...

Although endovascular stenting has been used as an interventional therapy to treat cardio- and cerebro-vascular diseases, it is associated with recurrent vascular diseases following stent thrombosis and in-stent restenosis. In this study, a metallic stent was coated with dopamine-conjugated hyaluronic acid with different ratios of catechol group to improve hemocompatibility and re-endothelializ...

Hyaluronic acid/Hyaluronan (HA) is an important component of the extracellular matrix dermis. HYBID (HA-Binding protein Involved in HA Depolymerization), also known as KIAA1199/CEMIP, plays a key role degradation large (>1000 kDa) into intermediate size fragments with molecular weights 10 kDa to 100 kDa. Recently, we have demonstrated that Artemisia capillaris flower extract suppresses histamin...

Ogston & Phelps (1961) found that hyaluronic acid markedly affects the partition of diffusible macromolecules between solutions of the polysaccharide and buffer. The authors explain the phenomenon as a steric exclusion of macromolecular solutes from solutions containing randomly coiled hyaluronic acid chains. From these results one can expect that hyaluronic acid and similar substances would ex...

BACKGROUND AND PURPOSE Dextranomer/hyaluronic acid copolymer implants are used in treating velopharyngeal insufficiency. These posterior nasopharyngeal implants can be mistaken for pathologic conditions such as retropharyngeal abscess on imaging. We studied the imaging appearance of dextranomer/hyaluronic acid copolymer implants in patients treated for velopharyngeal insufficiency. MATERIALS ...

An affinity immunological procedure for hyaluronic acid detection on tissue sections is described. This new, sensitive, and specific technique is based on the high affinity of hyaluronectin for hyaluronic acid, utilizing anti-hyaluronectin-hyaluronectin immune complexes. Elimination of binding when the reagent was supplemented with hyaluronic acid or when Streptomyces hyaluronidase-digested tis...

A high degree of viscosity is the most striking physical attribute of normal synovial fluid. Although its direct relationship to the lubrication of joints remains uncertain, this viscosity still reflects physiologically important properties of hyaluronic acid. The anomalous viscosity which is a particular feature of hyaluronic acid in synovial fluid depends not only on the concentration and pol...

Rheumatoid arthritis *is considered a disease which involves the connective tissue and supporting structures of the body with its primary nidus in the interfibrillar ground substance of these structures (1). The ground substances are thought to be composed of mucopolysaccharide-protein complexes. The nature of two of the polysaccharides is known-chondroitin sulfuric acid and hyaluronic acid. Th...

CD44 is a cell surface receptor for the glycosaminoglycan hyaluronan (HA). Not all CD44-positive cells bind HA, and binding ability is strictly regulated. Three different HA binding states have been defined: inactive, inducible (by certain CD44-specific monoclonal antibodies), and constitutively active. The observation that sets of genetically related cell lines representing different HA bindin...