UNLABELLED Diagnosing the presence of cirrhosis is crucial for the management of patients with C282Y hereditary hemochromatosis (HH). HH patients with serum ferritin >1,000 microg/L are at risk of cirrhosis; however, the majority of these patients do not have cirrhosis. Noninvasive markers of hepatic fibrosis may assist in determining which patients with a serum ferritin >1,000 microg/L have ci...

This chapter discusses two protocols that are used throughout the remaining chapters. These protocols and experimental data comprise the early preliminary work of this dissertation. The first protocol is the synthesis of photocrosslinkable glycidyl methacrylate modified hyaluronic acid (GMHA). This derivative was synthesized by the reaction of glycidyl methacrylate with HA in a solvent mixture ...

s-The uronic acid-containing glycosaminoglycans present in the brains of rat, monkey, chicken, sheep and rabbit were isolated into various fractions by combining the cetyl pyridinium procedure and DEAE-Sephadex column Chromatography. The analyses of the fractions show that hyaluronic acid, chondroitin4sulphate, chondroitin-6-sulphate, heparan sulphate and a testicular hyaluronidase-resistant ga...

Hyaluronidase has been investigated in various strains of pneumococci and hemolytic streptococci, and in some material of animal origin. The enzyme activity was measured by a viscosimetric method using as a substrate a fluid containing hyaluronic acid as the viscous component, and by the hydrolysis of pure hyaluronic acid into its reducing components. In pneumococci the enzyme was demonstrated ...

BACKGROUND Hyaluronic acid filler has been documented in the treatment of atrophic depressed acne scars relatively frequently in the literature but rarely in chronic depressed traumatic atrophic facial scars. METHODS This case report discusses the use of hyaluronic acid fillers in the correction of a post-traumatic facial atrophic scar on the right cheek. RESULTS The right cheek scar was su...

BACKGROUND We produced a novel model of bladder outlet obstruction (BOO) by periurethral injection of hyaluronic acid and compared the cystometric features, postoperative complications, and histopathological changes of that model with that of traditional open surgery. METHODS Forty female Sprague-Dawley rats were divided into three groups. Fifteen rats were subcutaneously injected with 0.2 ml...

Fluid from normal synovial joints contains about 3 mg./ml. hyaluronic acid (Hamerman and Schuster, 1958). Otherwise, it resembles an ultrafiltrate of plasma, but with a total protein concentration of 13 mg./ml. (Balazs, Watson, Duff, and Roseman, 1967), which is about one-fifth of that in plasma. With the exception of a tiny fraction bound to hyaluronic acid (Sandson and Hamerman, 1962), the pr...

The mucopolysaccharide, hyaluronic acid, is an important component of both mammals and pathogenic streptococci. This high molecular weight polymer is synthesized by a membrane-associated, multisubunit hyaluronate synthase which utilizes UDP-glucuronic acid and UDP-N-acetylglucosamine as substrates. Using the photoaffinity probe, [beta-32P]5-azido-UDP-glucuronic acid, three streptococcal membran...

INTRODUCTION recently, the viscoelastic properties of hyaluronic acid (HA) on liquid connective tissue have been proposed for the treatment of tendinopathies. Some fundamental studies show encouraging results on hyaluronic acid's ability to promote tendon gliding and reduce adhesion as well as to improve tendon architectural organisation. Some observations also support its use in a clinical set...