in this paper, we introduce hybrid of block-pulse functions and bernstein polynomials and derive operational matrices of integration, dual, differentiation, product and delay of these hybrid functions by a general procedure that can be used for other polynomials or orthogonal functions. then, we utilize them to solvedelay differential equations and time-delay system. the method is based upon ex...

The events of the civil-military dictatorship in Brazil carry disputed narratives concerning episodes aforementioned regimen, precluding, above all, those whose lives were marked by violence, torture and exile promoted Brazilian State, actions armed forces civil support US endorsement. Based on this socio-historical context, following study addresses adults who had their childhood teenagerhood ...

PURPOSE To evaluate whether elderly patients with metastatic colorectal cancer (mCRC) receive chemotherapy of suboptimal intensity and duration, mainly due to fears of poor compliance and/or excessive toxicity. METHODS We carried out a retrospective analysis in a series of 94 mCRC patients. Using the cut-off of 70 years, we compared elderly patients with their younger counterparts in terms of...

BACKGROUND Regimen change is a major challenge for the sustainability of human immunodeficiency virus (HIV) treatment program. In a resource limited setting where treatment options are limited, designing strategies to increase the durability of original regimen are essential. However, information's on rate of initial regimen change and its predictors is scarce in Ethiopia. Therefore, the purpos...

Baculovirus (BV) is a promising gene therapy vector and typically requires readministration because BV mediates transient expression. However, how the prime-boost regimen triggers BV-specific adaptive responses and their impacts on BV readministration, transgene expression, and therapeutic/vaccine efficacy remain unknown. Here we unraveled that BV injection into BALB/c mice induced the producti...

To understand the mechanisms controlling hematopoietic engraftment in untreated, normal recipients, we investigated the fate of parental, donor hematopoietic stem cells after apparent graft failures in unconditioned F1 hybrid recipient mice. By administering an anti-host H-2K monoclonal antibody, which targets host cells but spares the donor, we found that chimerism could be induced by delayed ...

OBJECTIVE To investigate individual pretreatment serum human chorionic gonadotropin (hCG) cutoff value for medical treatment success with single-dose and multi-dose regimen of methotrexate in tubal ectopic pregnancy. METHODS Eighty-five women who received methotrexate for the treatment of tubal ectopic pregnancy during 2003 to 2015 were selected. Fifty-three women received a single-dose regim...