Previously the author carrid out the intravenous glucose tolerance test with rats, and reported that the glucose tolerance curve for the adrenalectomized animal returned to the pre-operative level on the administration of hydrocortisone acetate (Tobe, 1957). Recently new compounds representing modifications of cortisone and hydrocortisone have appeared. Fried and Sabo(1953, 1954)showed that hal...

Cortisol has a distinct circadian rhythm with low concentrations at night, rising in the early hours of the morning, peaking on waking and declining over the day to low concentrations in the evening. Loss of this circadian rhythm, as seen in jetlag and shift work, is associated with fatigue in the short term and diabetes and obesity in the medium to long term. Patients with adrenal insufficienc...

OBJECTIVE To investigate the efficacy of continuous infusion of hydrocortisone with or without chlorpheniramine bolus against early adverse reactions to polyspecific antivenom. DESIGN AND SETTING Prospective, double-blind, randomised, placebo-controlled trial at General Hospital, Anuradhapura, Sri Lanka. SUBJECTS 52 patients with snake envenoming were randomised to receive infusion of hydro...

Addition of hydrocortisone to the medium of a clonal strain of rat pituitary cells (GH 3) stimulated the rate of production of growth hormone . The stimulation had a lag period of about 24 hr, reached a maximum at 70-100 hr, and was observed at a hydrocortisone concentration as low as 5 X 10 8 M. Cells maximally stimulated with 3 X 10 -s s .s hydrocortisone produced 50-160 μg growth hormone/mg ...

BACKGROUND Laparoscopic cholecystectomy is associated with shorter hospital stay and less pain in comparison to open surgery. The aim of this study was to evaluate the effect of intraperitoneal hydrocortisone on pain relief following laparoscopic cholecystectomy. METHODS Sixty two patients were enrolled in a double-blind, randomized clinical trial. Patients randomly received intraperitoneal i...

INTRODUCTION Hypothalamic hypopituitarism is relatively rare cause of secondary adrenal deficiency which is often accompanied by severe hypoglycemia. Hydrocortisone replacement therapy is essential for this condition, but gastrointestinal symptom such as nausea and vomiting is not well-recognized adverse effect of hydrocortisone. CASE DESCRIPTION A 64-year-old-woman was referred to our hospit...

BACKGROUND Bilirubin has anti-oxidative and anti-inflammatory properties, which may explain its proposed protective effects on the development of cardiometabolic disorders. Glucocorticoids affect heme oxygenase regulation in vitro, which plays a key role in bilirubin production. Effects of variations in glucocorticoid exposure on circulating bilirubin levels in humans are unknown. Here we teste...

Abnormal regulation of collagen synthesis has been observed in fibroblasts from keloids, benign collagenous tumors that develop as a result of an inherited defect in dermal wound healing. Hydrocortisone reduces the rate of collagen synthesis in fibroblasts from normal adult dermis and scars, but fails to down regulate collagen synthesis in keloid-derived fibroblasts. We show here that loss of g...